Inhibition of α/β-K6P2W18O62•10H2O on the Activity of Mushroom Tyrosinase and Its Antimicrobial Effects

被引：0

作者：

Hu Xi-yu ^{[2
]}

Chen Bing-nian ^{[1
]}

Wang Li ^{[2
]}

Chen Fa-he ^{[2
]}

机构：

[1] Xiamen Univ, Xiamen Univ Hosp, Zhongshan Hosp, Yanwu Affiliated Hosp, Xiamen 361005, Peoples R China

[2] Jimei Univ, Sch Bioengn, Xiamen 361021, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2012年 / 28卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Polyoxometalate; Mushroom tyrosianse; Inhibition; Antimicrobial activity; IONIC LIQUID; ELECTROCATALYTIC ACTIVITIES; KINETICS; ACID; DIPHENOLASE; COMPLEXES; CATALYSIS; OXIDATION; STRATEGY; CLUSTERS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dawson-type phosphotungstic polyoxometalate alpha/beta-K6P2W18O62 center dot 10H(2)O(P2W18) was synthesized and its inhibitory effect on the mushroom tyrosinase was investigated. It could inhibit diphenolase activity of mushroom tyrosinase as an irreversible inhibitor. When the concentration of the enzyme reached 0.0176 mg/mL, the concentration of P2W18 leading to 50% activity lost(IC50) was 0.05 mmol/L for monophcnolase and 0.64 mmol/L for diphenolase. In addition, the antimicrobial activity of P2W18 was evaluated by zone of inhibition test. The results show that P2W18 possesses effective antimicrobial ability against Escherichia coli, Bacillus subtilis, yeast, especially Escherichia coli and yeast.

引用

页码：862 / 865

页数：4

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