Single Cell Profiling of BCMA Naive Vs Refractory Relapsed Myeloma Patients Reveals Unique Transcriptomic Profiles in Tumor and Microenvironment

被引：0
|
作者：
Dang, Minghao [1 ]
Qin, Li [2 ]
Tan, Wei [2 ]
Dong, Liping [2 ]
Lee, Hans C. [3 ]
Patel, Krina [2 ]
Rueda, Luz Yurany Moreno [2 ]
Lin, Pei [4 ]
Bansal, Hima [2 ]
Berrios, David [2 ]
Thomas, Sheeba K. [2 ]
Weber, Donna M. [2 ]
Symer, David E. [2 ]
Wang, Linghua [1 ]
Manasanch, Elisabet E. [2 ]
Orlowski, Robert Z. [3 ,5 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Genom Med, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma & Myeloma, Houston, TX 77030 USA
[3] MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Houston, TX USA
[4] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA
[5] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
来源：
BLOOD | 2022年 / 140卷
关键词：
D O I：
10.1182/blood-2022-165540
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：7122 / 7124
页数：3
相关论文
共 50 条
  • [1] Outcomes of Patients Who Are BCMA (B-cell maturation Antigen) Directed Therapy (BDT) Exposed Vs BCMA Naive in Penta-Relapsed Refractory Multiple Myeloma (RRMM)
    Mammadzadeh, Aytaj
    Peng, Fulei
    Atrash, Shebli
    Hashmi, Hamza
    Mohan, Meera
    Alkharabsheh, Omar
    Afrough, Aimaz
    Cui, Wei
    Mahmoudjafari, Zahra
    Abdallah, Al-Ola
    BLOOD, 2022, 140 : 4277 - 4278
  • [2] Clinical outcomes and microenvironment profiling in relapsed/refractory multiple myeloma patients with extramedullary disease receiving anti-BCMA CAR T-cell-based therapy
    Qi, Yuekun
    Li, Hujun
    Qi, Kunming
    Zhu, Feng
    Cheng, Hai
    Chen, Wei
    Yan, Zhiling
    Li, Depeng
    Sang, Wei
    Fei, Xiaoming
    Gu, Weiying
    Miao, Yuqing
    Huang, Hongming
    Wang, Ying
    Qiu, Tingting
    Qiao, Jianlin
    Pan, Bin
    Shi, Ming
    Wang, Gang
    Li, Zhenyu
    Zheng, Junnian
    Xu, Kailin
    Cao, Jiang
    AMERICAN JOURNAL OF HEMATOLOGY, 2024, 99 (12) : 2286 - 2295
  • [3] Pan-Cancer Spatial Transcriptomic Profiling Reveals a Unique Tumor Immune Microenvironment in Liver Metastases
    Fischer, G.
    Dryg, I.
    Chen, J.
    Shi, Y.
    Weirather, J.
    Haq, R.
    Rodig, S.
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2024, 26 (11): : S109 - S109
  • [4] Iberdomide induces activation and proliferation of innate and adaptive immune cell subsets in the tumor microenvironment of relapsed/refractory myeloma patients
    Van Oekelen, Oliver
    Amatangelo, Michael
    Guo, Manman
    Updahyaya, Bhaskar
    Cribbs, Adam
    Kelly, Geoffrey
    Patel, Manishkumar
    Kim-Schulze, Seunghee
    Flynt, Erin
    Lagana, Alessandro
    Gooding, Sarah
    Jagannath, Sundar
    Pierceall, William
    Thakurta, Anjan
    Oppermann, Udo
    Parekh, Samir
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 : S86 - S87
  • [5] Infectious complications in patients with relapsed refractory multiple myeloma after BCMA CAR T-cell therapy
    Kambhampati, Swetha
    Sheng, Ying
    Huang, Chiung-Yu
    Bylsma, Sophia
    Lo, Mimi
    Kennedy, Vanessa
    Natsuhara, Kelsey
    Martin, Thomas
    Wolf, Jeffrey
    Shah, Nina
    Wong, Sandy W.
    BLOOD ADVANCES, 2022, 6 (07) : 2045 - 2054
  • [6] Single-Cell Profiling Reveals Contribution of Tumor Extrinsic and Intrinsic Factors to BCMA-Targeted CAR-T Cell Efficacy in Multiple Myeloma
    Melnekoff, David T.
    Ghodke-Puranik, Yogita
    Van Oekelen, Oliver
    Aleman, Adolfo
    Upadhyaya, Bhaskar
    Sebra, Robert
    Jagannath, Sundar
    Lagana, Alessandro
    Parekh, Samir
    BLOOD, 2021, 138
  • [7] Single-Cell Profiling of CD8 Landscape in Treatment Naive and Relapsed/Refractory AML Patients Reveals Distinct Effector Cellular States Predictive of Outcomes
    Desai, Poonam
    Wang, Bofei
    Jelloul, Fatima Zahra
    Alatrash, Gheath
    Baran, Natalia
    Deng, Qing
    Green, Michael R.
    Daver, Naval
    Konopleva, Marina
    Futreal, Andy
    Hao, Dapeng
    Abbas, Hussein A.
    BLOOD, 2022, 140 : 9144 - 9145
  • [8] Increased Bone Turnover and Decreased BCMA Levels in Patients with Response to Anti-BCMA CAR T Cell Therapy in Relapsed/Refractory Multiple Myeloma
    Ussmann, Jule
    Fischer, Luise
    Born, Patrick
    Grieb, Nora
    Hoffmann, Sandra
    Baber, Ronny
    Wang, Song-Yau
    Kloetzer, Christina
    Heyn, Simone
    Herling, Marco
    Herling, Carmen
    Jentzsch, Madlen
    Franke, Georg-Nikolaus
    Hofbauer, Lorenz
    Platzbecker, Uwe
    Vucinic, Vladan
    Weidner, Heike
    Merz, Maximilian
    BLOOD, 2023, 142
  • [9] Single-Cell Transcriptomics Reveals the Complexity of the Tumor Microenvironment of Treatment-Naive Osteosarcoma
    Liu, Yun
    Feng, Wenyu
    Dai, Yan
    Bao, Mengying
    Yuan, Zhenchao
    He, Mingwei
    Qin, Zhaojie
    Liao, Shijie
    He, Juliang
    Huang, Qian
    Yu, Zhenyuan
    Zeng, Yanyu
    Guo, Binqian
    Huang, Rong
    Yang, Rirong
    Jiang, Yonghua
    Liao, Jinling
    Xiao, Zengming
    Zhan, Xinli
    Lin, Chengsen
    Xu, Jiake
    Ye, Yu
    Ma, Jie
    Wei, Qingjun
    Mo, Zengnan
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [10] Single-Cell Transcriptomic Analysis Reveals BCMA CAR-T Cell Dynamics in a Patient with Refractory Primary Plasma Cell Leukemia
    Li, Xue
    Guo, Xin
    Zhu, Yuqing
    Wei, Guoqing
    Zhang, Yanlei
    Li, Xia
    Xu, Huijun
    Cui, Jiazhen
    Wu, Wenjun
    He, Jingsong
    Ritchie, Matthew E.
    Weiskittel, Taylor M.
    Li, Hu
    Yu, Hua
    Ding, Lijuan
    Shao, Mi
    Luo, Qian
    Xu, Xiaoxiao
    Teng, Xinyi
    Chang, Alex H.
    Zhang, Jin
    Huang, He
    Hu, Yongxian
    MOLECULAR THERAPY, 2021, 29 (02) : 645 - 657
12345