Photoprotective effects of Bifidobacterium breve supplementation against skin damage induced by ultraviolet irradiation in hairless mice

被引:23
|
作者
Sugimoto, Saho [1 ]
Ishii, Yuki [1 ]
Izawa, Naoki [1 ]
Masuoka, Norie [1 ]
Kano, Mitsuyoshi [1 ]
Sone, Toshiro [1 ]
Chiba, Katsuyoshi [1 ]
Miyazaki, Kouji [1 ]
Ishikawa, Fumiyasu [1 ]
机构
[1] Yakult Cent Inst Microbiol Res, Pharmaceut & Cosmet Res Dept, Tokyo 1868650, Japan
关键词
probiotic; skin; ultraviolet; CUTANEOUS IMMUNE HOMEOSTASIS; MECHANICAL-PROPERTIES; ELASTASE ACTIVITY; UV EXPOSURE; MOUSE SKIN; IN-VIVO; PROBIOTICS; BACTERIA; WRINKLES; QUANTIFICATION;
D O I
10.1111/phpp.12006
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Probiotics have been considered to affect not only the gut but also the skin. This study aimed at examining whether oral administration of live Bifidobacterium breve strain Yakult (BBY), a typical probiotic, could exert photoprotective effects in hairless mouse skin. Methods: BBY cell suspensions and fermented milk containing BBY (BBYM) were orally administered to hairless mice for 9 and 14 days, respectively. Mice were irradiated with ultraviolet (UV) light daily for the last four consecutive days. Twenty-four hours after the final irradiation, skin elasticity, appearance, elastase activity and interleukin (IL)-1 beta levels were evaluated in the dorsal skin. Results: BBY and BBYM significantly prevented UV-induced deleterious changes in skin elasticity and appearance. BBY suppressed the increases in both elastase activity and IL-1 beta levels in the skin. There was a significant negative correlation between elastase activity and the ratio of elastic recovery to total deformation and a significant positive correlation between elastase activity and the area ratio of furrows, independent of UV irradiation or BBY administration. Conclusion: Our findings suggest that oral administration of probiotic BBY has the potential to prevent UV-induced skin damage, supporting the hypothesis that probiotics are beneficial not only to the intestine but also to the skin.
引用
收藏
页码:312 / 319
页数:8
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