Role of calbindin-D28K in estrogen treatment for Parkinson's disease

被引：6

作者：

Wane, Chunhua ^{[1
,2
,3
]}

Jiang, Chao ^{[1
]}

Yuan, Honghua ^{[1
]}

Xiao, Chenghua ^{[2
]}

Gao, Dianshuai ^{[1
,2
]}

机构：

[1] Xuzhou Med Coll, Dept Neurobiol, Xuzhou 221002, Jiangsu, Peoples R China

[2] Xuzhou Med Coll, Dept Neurol, Xuzhou 221002, Jiangsu, Peoples R China

[3] Funing Cty Peoples Hosp, Dept Neurol, Yancheng 224400, Jiangsu, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2013年 / 8卷 / 08期

关键词：

neural regeneration; neurodegenerative diseases; estrogen; calbindin-D28K; Parkinson's disease; dopaminergic neuron; tyrosine hydroxylase; photographs-containing paper; neuroregeneration; MPTP MOUSE MODEL; DOPAMINERGIC-NEURONS; SIGNALING PATHWAY; G-PROTEIN; ESTRADIOL; INVOLVEMENT; EXPRESSION; BINDING; KINASE; 17-BETA-ESTRADIOL;

D O I：

10.3969/j.issn.1673-5374.2013.08.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Studies have shown that estrogen has neuroprotective effects on the nigrostriatal system. The present study established a Parkinson's disease model in C57BL/6 mice by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrapyridine. The mice were subjected to 17 beta estradiol injection into the lateral ventricle. Immunofluorescence double staining showed that estrogen increased tyrosine hydroxylase and calbindin-D28K expression and co-expression in dopaminergic neurons of midbrain substantia nigra pars compacta of model mice. Behavior experiments showed that estrogen improved swimming and hanging behaviors in this mouse model of Parkinson's disease.

引用

页码：702 / 707

页数：6

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