Prolonged serum half-life of a recombinant fusion protein linking activated coagulation factor vii with albumin (rVIIa-FP) in different preclinical species

被引:0
|
作者
Dickneite, G. [1 ]
Zollner, S. [1 ]
Weimer, T. [1 ]
Schmidbauer, S. [1 ]
Raquet, E. [1 ]
Mueller-Cohrs, J. [1 ]
Pragst, I [1 ]
Schulte, S. [1 ]
机构
[1] CSL Behring GmbH, Preclin R&D, Marburg, Germany
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
P-TU-246
引用
下载
收藏
页码:385 / 386
页数:2
相关论文
共 50 条
  • [1] Prolonged Plasma Half-Life and Hemostatic Efficacy of a Recombinant Fusion Protein Linking Activated Coagulation Factor VII with Albumin (rVIIa-FP)
    Zollner, S.
    Schuermann, D.
    Raquet, E.
    Bliss, S.
    Weimer, T.
    Mueller-Cohrs, J.
    Pragst, I.
    Dickneite, G.
    Schulte, S.
    HAEMOPHILIA, 2012, 18 : 97 - 98
  • [2] Pre-clinical characteristics of a recombinant fusion protein linking activated coagulation factor VII with albumin (rVIIa-FP)
    Zollner, S.
    Schuermann, D.
    Kaspereit, F.
    Krege, W.
    Weimer, T.
    Mueller-Cohrs, J.
    Pragst, I.
    Dickneite, G.
    Schulte, S.
    HAEMOPHILIA, 2012, 18 : 98 - 98
  • [3] Preclinical characteristics of a novel recombinant fusion protein linking coagulation factor VIIa with albumin (rVIIa-FP)
    Zollner, S.
    Schuermann, D.
    Weimer, T.
    Bliss, S.
    Mueller-Cohrs, J.
    Pragst, I.
    Dickneite, G.
    Schulte, S.
    HAEMOPHILIA, 2012, 18 : 42 - 42
  • [4] Pharmacokinetics of a recombinant albumin-fused, human coagulation factor VIIa (rVIIa-FP) exhibiting prolonged serum half-life in different animal species
    Zollner, S.
    Weimer, T.
    Schmidbauer, S.
    Raquet, E.
    Mueller-Cohrs, J.
    Schulte, S.
    HAEMOPHILIA, 2010, 16 : 33 - 33
  • [5] Pharmacokinetics and pharmacodynamics of a recombinant fusion protein linking activated coagulation factor VII with human albumin (rVIIa-FP) in patients with congenital FVII deficiency
    Laros-van Gorkom, Britta
    Holme, Pal Andre
    Joch, Christine
    Rogosch, Tobias
    Feussner, Annette
    McKeand, William
    Roberts, John
    van Heerde, Waander
    HEMATOLOGY, 2020, 25 (01) : 17 - 25
  • [6] Pharmacological characteristics of a novel, recombinant fusion protein linking coagulation factor VIIa with albumin (rVIIa-FP)
    Zollner, S.
    Schuermann, D.
    Raquet, E.
    Mueller-Cohrs, J.
    Weimer, T.
    Pragst, I.
    Dickneite, G.
    Schulte, S.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2014, 12 (02) : 220 - 228
  • [7] Pre-clinical safety and prolonged pharmacokinetic/pharmacodynamic (PK/PD) properties of a recombinant fusion protein linking activated coagulation factor VII with albumin (rVIIa-FP)
    Zollner, S.
    Schuermann, D.
    Kaspereit, F.
    Krege, W.
    Weimer, T.
    Mueller-Cohrs, J.
    Pragst, I
    Dickneite, G.
    Schulte, S.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2013, 11 : 480 - 480
  • [8] A recombinant fusion protein linking activated coagulation factor VII with albumin (rVIIa-FP) interacts with endothelial cell protein C receptor (EPCR) and is internalized in vitro
    Cattepoel, Susann
    Spirig, Rolf
    Herzog, Eva
    Miescher, Sylvia
    Zollner, Sabine
    HAEMOPHILIA, 2014, 20 : 28 - 28
  • [9] Safety and pharmacokinetics of a recombinant fusion protein-linking coagulation factor VIIa with albumin (rVIIa-FP) in healthy volunteers
    Veldman, A.
    Easton, R.
    Jung, K.
    Moises, T.
    Lawo, J. P.
    Joch, C.
    Daehler, A.
    Bensen-Kennedy, D.
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2013, 11 : 800 - 801
  • [10] Recombinant fusion protein linking factor VIIa with albumin (rVIIa-FP): Tissue distribution in rats
    Herzog, Eva
    Harris, Stephen
    McEwen, Andrew
    Henson, Claire
    Pragst, Ingo
    Dickneite, Gerhard
    Schulte, Stefan
    Zollner, Sabine
    THROMBOSIS RESEARCH, 2014, 134 (02) : 495 - 502