Use of succinate-containing agents in the treatment of infectious diseases

被引：3
|
作者：
Tikhonova, E. O. [1 ]
Lyapina, E. P. [1 ,2 ]
Shul'dyakov, A. A. [1 ]
Satarova, S. A. [1 ]
机构：
[1] VI Razumovsky Saratov State Med Univ, Minist Hlth Russia, Saratov, Russia
[2] Saratov Res Inst Rural Hyg, Russian Fed Serv Supervis Consumer Rights Protect, Saratov, Russia
来源：
TERAPEVTICHESKII ARKHIV | 2016年 / 88卷 / 11期
关键词：
hypoxia; succinic acid; infectious diseases; succinate-containing drugs; enteric infections; HIF-1;
D O I：
10.17116/terarkh20168811121-127
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The review gives data that reveal the role of succinic acid in providing cells with energy and oxygen under hypoxic conditions. It presents the results of clinical and experimental studies to evaluate the efficacy of succinate-containing drugs in the combination therapy of infectious diseases. The spectrum of biological effects of these drugs, which is provided by the synergy of their active ingredients, is considered.
引用
收藏
页码：121 / 127
页数：9
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