Natural autoantibodies and associated B cells in immunity and autoimmunity

被引:41
|
作者
Mannoor, Kaiissar [1 ]
Xu, Yang [2 ]
Chen, Ching [1 ]
机构
[1] Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA
[2] Cent S Univ, Xiangya Sch Med, Changsha, Hunan, Peoples R China
关键词
natural antibodies; autoantibodies; B cells; autoimmunity; SYSTEMIC-LUPUS-ERYTHEMATOSUS; IMMUNOGLOBULIN-M ANTIBODIES; ANTI-DSDNA ANTIBODIES; POLYREACTIVE ANTIBODIES; MONOCLONAL-ANTIBODIES; SOMATIC MUTATION; APOPTOTIC CELLS; INFLUENZA-VIRUS; T-CELLS; VH-GENE;
D O I
10.3109/08916934.2012.748753
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A substantial proportion of circulating antibodies in healthy individuals exhibit self-reactivity. These antibodies, referred to as natural autoantibodies, are thought to arise naturally without actual antigen stimulation as they are present in human cord blood and in mice housed in germfree conditions and fed an antigen-free diet. Natural autoantibodies are mainly of the IgM class, unmutated, and typically polyreactive. They provide critical early protection against pathogens, and play important roles in maintenance of homeostasis and modulation of innate and adaptive immune responses, thereby conferring protection from rampant autoimmune and inflammatory injuries. In this review, we summarize current information regarding the properties of natural autoantibodies and the B cells that produce them, their roles in immunity and autoimmunity, their mechanisms of action, and their therapeutic potential.
引用
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页码:138 / 147
页数:10
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