Covalent grafting folate on Au electrode via click chemistry

被引：8
|
作者：
Pang, Yuehong [1 ]
Ge, Zhaoqiang [1 ]
Liu, Yong [1 ]
Shen, Xiaofang [1 ]
机构：
[1] Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Peoples R China
来源：
ELECTROCHEMISTRY COMMUNICATIONS | 2012年 / 23卷
基金：
中国国家自然科学基金;
关键词：
Click reaction; Folate; Cancer cells; Electrochemistry; CANCER;
D O I：
10.1016/j.elecom.2012.07.018
中图分类号：
O646 [电化学、电解、磁化学];
学科分类号：
081704 ;
摘要：
Covalently conjugating folate on Au surface was achieved via click chemistry, copper (I)-catalyzed azide-alkyne cycloaddition reaction. Human leukemia K562 cells were used as a model system to investigate capturing cancer cells by folate-targeted electrode. Scanning optical microscopy and electrochemical method were used to monitor the capture of K562 cells on folate-clicked electrode. (c) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：98 / 101
页数：4
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