Changes in amygdala neural activity that occur with the extinction of context-dependent conditioned fear stress

被引：20
|
作者：
Izumi, Takeshi [1 ]
Inoue, Takeshi [2 ]
Kato, Akiko [2 ]
Kitaichi, Yuji [2 ]
Nakagawa, Shin [2 ]
Koyama, Tsukasa [2 ]
机构：
[1] Hokkaido Univ, Grad Sch Med, Dept Neuropharmacol, Sapporo, Hokkaido 0608638, Japan
[2] Hokkaido Univ, Grad Sch Med, Dept Psychiat, Sapporo, Hokkaido 0608638, Japan
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2008年 / 90卷 / 03期
关键词：
amygdala; basal nucleus; conditioned fear stress (CFS); cyclic AMP responsive element-binding protein (CREB); extinction;
D O I：
10.1016/j.pbb.2008.02.023
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The purpose of the present study was to characterize functional changes in the amygdala that accompany the extinction of context-dependent conditioned fear stress in a rat, an animal model of anxiety. Specifically, the effect of extinction of conditioned fear-induced cyclic AMP responsive element-binding protein (CREB) phosphorylation in the amygdala was investigated using immunohistochemistry. Experiments demonstrated that CREB phosphorylation in the basal nucleus of the amygdala decreased with the extinction of context-dependent conditioned fear-induced freezing behavior. These data suggest that the basal nucleus of the amygdala plays an essential role in the expression of context-dependent conditioned fear. Further, this is the first study to demonstrate that CREB phosphorylation in the basal nucleus of the amygdala changes in parallel with the extinction of context-dependent conditioned fear. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：297 / 304
页数：8
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