Steroid refractory psoriasiform cutaneous graft versus host disease successfully treated by extracorporeal photopheresis: A case report

被引：8
|
作者：
Demiriz, I. Sirinoglu
Tekgunduz, E.
Tetik, A.
Kayikci, O.
Altuntas, F. [1 ]
机构：
[1] Ankara Oncol Educ & Res Hosp, Dept Hematol, Ankara, Turkey
来源：
TRANSFUSION AND APHERESIS SCIENCE | 2013年 / 48卷 / 01期
关键词：
Allogeneic hematopoietic stem cell transplantation; Graft-versus-host disease (GVHD); Psoriasis; Extracorporeal photopheresis (ECP); T-CELL LYMPHOMA; PHOTOCHEMOTHERAPY; GVHD;
D O I：
10.1016/j.transci.2012.07.018
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Graft-versus-host disease (GVHD) is a frequent complication occurring after allogeneic hematopoietic stem cell transplantation. It can be classified as acute and chronic GVHD based on the time of onset following transplantation and clinical presentation. Cutaneous involvement is the most common feature of acute GVHD, with maculopapular exanthema and perifollicular papular lesions. Steroid refractory GVHD is associated with a significant morbidity and mortality. We present a very rare case with acute cutaneous GVHD mimicking psoriasis vulgaris occurring after allogeneic peripheral blood stem cell transplantation for chronic lymphocytic leukemia. The patient's rash resembled psoriasis vulgaris and showed histologic features of both psoriasis and acute GVHD. Despite concomitant cyclosporine A and methylprednisolone therapy no response was obtained. Therefore, we administered extracorporeal photopheresis and achieved the desired therapeutic effect. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：109 / 111
页数：3
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