CTLA-4 blockade improves the balance of CD8+effector and CD4+regulatory T cells following adoptive cell transfer melanoma immunotherapy.

被引:0
|
作者
Wentworth, Lucy [1 ]
Mahvi, David A. [2 ]
Meyers, Justin V. [2 ]
Durbin, Samantha [2 ]
Cho, Clifford S. [1 ]
机构
[1] William S Middleton Mem VA Hosp, Madison, WI USA
[2] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA
关键词
D O I
10.1158/1538-7445.TUMIMM2012-A37
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A37
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Blockade of CTLA-4 on CD4+ CD25+ regulatory T cells abrogates their function in vivo
    Read, Simon
    Greenwald, Rebecca
    Izcue, Ana
    Robinson, Nicholas
    Mandelbrot, Didier
    Francisco, Loise
    Sharpe, Arlene H.
    Powrie, Fiona
    JOURNAL OF IMMUNOLOGY, 2006, 177 (07): : 4376 - 4383
  • [2] CTLA-4 blockade increases IFNγ-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients
    Liakou, Chrysoula I.
    Kamat, Ashish
    Tang, Derek Ng
    Chen, Hong
    Sun, Jingjing
    Troncoso, Patricia
    Logothetis, Christopher
    Sharma, Padmanee
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (39) : 14987 - 14992
  • [3] The molecular program of CD4+regulatory and effector T cell expansion in vitro
    Moro, Alejandro
    Yu, Aixin
    Nivelo, Luis
    Villarino, Alejandro
    Malek, Thomas
    JOURNAL OF IMMUNOLOGY, 2024, 212 (01):
  • [4] LDH inhibition boosts effector T cells while destabilizing regulatory T cells and improves responses to CTLA-4 blockade
    Verma, Svena
    Serganova, Inna
    Dong, Lauren
    Budhu, Sadna
    Mangarin, Levi
    Zappasodi, Roberta
    Merghoub, Taha
    Wolchok, Jedd D.
    CANCER RESEARCH, 2023, 83 (07)
  • [5] CTLA-4 Blockade Plus Adoptive T-Cell Transfer Promotes Optimal Melanoma Immunity in Mice
    Mahvi, David A.
    Meyers, Justin V.
    Tatar, Andrew J.
    Contreras, Amanda
    Suresh, Marulasiddappa
    Leverson, Glen E.
    Sen, Siddhartha
    Cho, Clifford S.
    JOURNAL OF IMMUNOTHERAPY, 2015, 38 (02) : 54 - 61
  • [6] CTLA-4 engagement and regulatory CD4+ CD25+ T cells independently control CD8+-mediated responses under costimulation blockade
    Coenen, Jeroen J. A.
    Koenen, Hans J. P. M.
    van Rijssen, Esther
    Boon, Louis
    Joosten, Irma
    Hilbrands, Luuk B.
    JOURNAL OF IMMUNOLOGY, 2006, 176 (09): : 5240 - 5246
  • [7] CTLA-4 engagement and regulatory CD4+CD25+ T cells independently control CD8+-mediated responses under costimulation blockade.
    Coenen, JJA
    Koenen, HJPM
    van Rijssen, E
    Boon, L
    Joosten, I
    Hilbrands, LB
    AMERICAN JOURNAL OF TRANSPLANTATION, 2005, 5 : 378 - 378
  • [9] Basis of CTLA-4 function in regulatory and conventional CD4+ T cells
    Tai, Xuguang
    Van Laethem, Francois
    Pobezinsky, Leonid
    Guinter, Terry
    Sharrow, Susan O.
    Adams, Anthony
    Granger, Larry
    Kruhlak, Michael
    Lindsten, Tullia
    Thompson, Craig B.
    Feigenbaum, Lionel
    Singer, Alfred
    BLOOD, 2012, 119 (22) : 5155 - 5163
  • [10] LDH INHIBITION IMPROVES RESPONSE TO CTLA-4 BLOCKADE BY ENHANCING EFFECTOR T CELL ACTIVITY AND IMPAIRING REGULATORY T CELL SUPPRESSION
    Verma, Svena
    Serganova, Inna
    Budhu, Sadna
    Dong, Lauren
    Mangarin, Levi
    Ko, Myat
    Blasberg, Ronald
    Zappasodi, Roberta
    Wolchok, Jedd
    Merghoub, Taha
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A942 - A942