Genetics of graft-versus-host disease: The major histocompatibility complex

被引：39
|
作者：
Petersdorf, Effie W. [1 ]
机构：
[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA
来源：
BLOOD REVIEWS | 2013年 / 27卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Major histocompatibility complex (MHC); HLA; Haplotype; Linkage disequilibrium (LD); Graft-versus-host disease (GVHD); Hematopoietic cell transplantation (HCT); Unrelated donor; Cord blood transplantation; Single nucleotide polymorphism (SNP); STEM-CELL TRANSPLANTATION; UMBILICAL-CORD BLOOD; BONE-MARROW-TRANSPLANTATION; KIR-LIGAND INCOMPATIBILITY; HLA CLASS-I; NONPERMISSIVE HLA-DPB1 DISPARITY; SINGLE-NUCLEOTIDE POLYMORPHISMS; NONINHERITED MATERNAL ANTIGENS; REDUCED RELAPSE RATE; HEAT-SHOCK PROTEINS;
D O I：
10.1016/j.blre.2012.10.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Graft-versus-host disease (GVHD) is a potentially life-threatening complication of allogeneic hematopoietic cell transplantation. Many genes are presumed to be involved in GVHD, but the best characterized genetic system is that of the human major histocompatibility complex (MHC) located on chromosome 6. Among the hundreds of genes located within the MHC region, the best known and characterized are the classical HLA genes, HLA-A, C, B, DRB1, DQB1, and DPB1. They play a fundamental role in T cell immune responses, and HLA-A, C, and B also function as ligands for the natural killer cell immunoglobulin-like receptors involved in innate immunity. This review highlights the state-of-the art in the field of histocompatibility and immunogenetics of the MHC with respect to genetic risk factors for GVHD. (C) 2012 Elsevier Ltd. All rights reserved.
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页码：1 / 12
页数：12
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