Tabebuialdehydes A-C, cyclopentene dialdehyde derivatives from the roots of Tabebuia rosea

Two new cyclopentene dialdehydes, tabebuialdehydes A and B (1 and 2) and a new dihydro-cyclopentalc[c]furan monoaldehyde, tabebuialdehyde C (3), along with ten known compounds were isolated from the roots of Tabebuia rosea. The structures of all isolated compounds were elucidated through their physical properties and by the use of spectroscopic methods, as well as comparisons with previous literature data Moreover, all isolated compounds were evaluated for their cytotoxicity (KB and HeLa cell lines). Compounds 6, 7 and 9 showed significant cytotoxicity against both KB and HeLa cells with IC50 values of 1.35 and 1.15, 0.53 and 0.77, 1.79 and 0.73 mu g/mL, respectively. (C) 2012 Elsevier B.V. All rights reserved.