Longitudinal Assessment of Bile Duct Loss in Primary Biliary Cholangitis

被引：1

作者：

Hercun, Julian ^{[1
]}

Noureddin, Mazen ^{[1
]}

Noureddin, Nabil ^{[1
]}

Eccleston, Jason ^{[1
]}

Woolridge, Daniel ^{[1
]}

Liang, T. Jake ^{[1
]}

Tana, Michele ^{[1
]}

Kleiner, David E. ^{[2
]}

Rodriguez, Gracia Viana ^{[1
]}

Koh, Christopher ^{[1
]}

Hoofnagle, Jay H. ^{[1
]}

Heller, Theo ^{[1
]}

机构：

[1] Natl Inst Diabet & Digest & Kidney Dis, Liver Dis Branch, Bethesda, MD 20892 USA

[2] NIH, NCI, Intramural Div, Lab Pathol, Bethesda, MD 20892 USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2022年 / 117卷 / 12期

关键词：

PORTAL-HYPERTENSION; CIRRHOSIS; OUTCOMES;

D O I：

10.14309/ajg.0000000000001985

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

INTRODUCTION:Bile duct involvement is a key finding of primary biliary cholangitis (PBC). The aim of this study was to evaluate baseline ductopenia and disease progression.METHODS:Retrospective longitudinal histological follow-up of treatment-naive patients with PBC.RESULTS:Eighty-three patients were included, with ductopenia correlated to fibrosis stage at baseline. The cumulative incidence of severe ductopenia remained stable after 5 years, whereas fibrosis continually increased over time. Baseline AST-to-Platelet Ratio Index and elevated alkaline phosphatase >2 times the normal with abnormal bilirubin were associated with ductopenia progression.DISCUSSION:Bile duct injury does not seem to follow the same course as fibrosis in PBC.

引用

页码：2075 / 2078

页数：4

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