Effects of Air Pollution and Blood Mitochondrial DNA Methylation on Markers of Heart Rate Variability

被引:89
|
作者
Byun, Hyang-Min [1 ]
Colicino, Elena [2 ]
Trevisi, Letizia [2 ]
Fan, Tianteng [2 ]
Christiani, David C. [2 ]
Baccarelli, Andrea A. [2 ]
机构
[1] Newcastle Univ, Inst Cellular Med, Human Nutr Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England
[2] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, 665 Huntington Ave, Boston, MA 02115 USA
来源
基金
美国国家卫生研究院;
关键词
air pollution; epigenetics; heart rate variability; mitochondria; particulate matter; PARTICULATE MATTER; CARDIOVASCULAR-DISEASE; EXPOSURE; EXPRESSION; PM2.5;
D O I
10.1161/JAHA.116.003218
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background-The mitochondrion is the primary target of oxidative stress in response to exogenous environments. Mitochondrial DNA (mtDNA) is independent from nuclear DNA and uses separate epigenetic machinery to regulate mtDNA methylation. The mtDNA damage induced by oxidative stress can cause mitochondrial dysfunction and is implicated in human diseases; however, mtDNA methylation has been largely overlooked in environmental studies relating to human disease. The purpose of this study was to examine the association between exposure to fine metal-rich particulates (particulate matter <2.5 mu m in diameter [PM2.5]) from welding in a boilermaker union and blood mtDNA methylation in relation to heart rate variability. Methods and Results-Forty-eight healthy men were recruited on multiple sampling cycles at the Boilermaker Union Local 29, located in Quincy, Massachusetts. We measured personal PM2.5 in the background ambient environment. We measured blood mtDNA methylation in the mtDNA promoter (D-loop) and genes essential for ATP synthesis (MT-TF and MT-RNR1) by bisulfite pyrosequencing. All analyses were adjusted for demographics, type of job, season, welding-work day, and mtDNA methylation experimental batch effect. The participants' PM2.5 exposure was significantly higher after a welding-work day (mean 0.38 mg/m(3)) than the background personal level (mean 0.15 mg/m(3), P<0.001). Blood mtDNA methylation in the D-loop promoter was associated with PM2.5 levels (beta=-0.99%, SE=0.41, P=0.02). MT-TF and MT-RNR1 methylation was not associated with PM2.5 exposure (beta=0.10%, SE=0.45, P=0.82). Interaction of PM2.5 exposure levels and D-loop promoter methylation was significantly associated with markers of heart rate variability. Conclusions-Blood mtDNA methylation levels were negatively associated with PM2.5 exposure and modified the adverse relationships between PM2.5 exposure and heart rate variability outcomes.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression
    Breton, Carrie V.
    Song, Ashley Y.
    Xiao, Jialin
    Kim, Su-Jeong
    Mehta, Hemal H.
    Wan, Junxiang
    Yen, Kelvin
    Sioutas, Constantinos
    Lurmann, Fred
    Xue, Shanyan
    Morgan, Todd E.
    Zhang, Junfeng
    Cohen, Pinchas
    [J]. MITOCHONDRION, 2019, 46 : 22 - 29
  • [2] Ambient particulate air pollution, heart rate variability, and blood markers of inflammation in a panel of elderly subjects
    Pope, CA
    Hansen, ML
    Long, RW
    Nielsen, KR
    Eatough, NL
    Wilson, WE
    Eatough, DJ
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2004, 112 (03) : 339 - 345
  • [3] Short-term effects of ambient gaseous air pollution on blood platelet mitochondrial DNA methylation and myocardial ischemia
    Jiang, Yunxing
    Chen, Juan
    Guo, Liqiong
    Lan, Yang
    Li, Ge
    Liu, Qisijing
    Li, Hongyu
    Deng, Furong
    Guo, Xinbiao
    Wu, Shaowei
    [J]. ENVIRONMENT INTERNATIONAL, 2024, 185
  • [4] Effects of air pollution on heart rate variability: A population-based study
    Park, SK
    O'Neill, M
    Vokonas, P
    Schwartz, J
    [J]. EPIDEMIOLOGY, 2003, 14 (05) : S98 - S98
  • [5] Effects of air pollution on heart rate variability: The VA Normative Aging Study
    Park, SK
    O'Neill, MS
    Vokonas, PS
    Sparrow, D
    Schwartz, J
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2005, 113 (03) : 304 - 309
  • [6] Heart rate variability associated with particulate air pollution
    Pope, CA
    Verrier, RL
    Lovett, EG
    Larson, AC
    Raizenne, ME
    Kanner, RE
    Schwartz, J
    Villegas, M
    Gold, DR
    Dockery, DW
    [J]. AMERICAN HEART JOURNAL, 1999, 138 (05) : 890 - 899
  • [7] The associations between exposure to ambient air pollution and coagulation markers and the potential effects of DNA methylation
    Chen, Yan
    Dong, Guang-Hui
    Li, Shuai
    Liu, Yuewei
    Li, Shanshan
    Guo, Yuming
    Wang, Chongjian
    Chen, Gongbo
    [J]. Journal of Hazardous Materials, 2024, 480
  • [8] Air pollution and DNA methylation: effects of exposure in humans
    Christopher F. Rider
    Chris Carlsten
    [J]. Clinical Epigenetics, 2019, 11
  • [9] Air pollution and DNA methylation: effects of exposure in humans
    Rider, Christopher F.
    Carlsten, Chris
    [J]. CLINICAL EPIGENETICS, 2019, 11 (01)
  • [10] Effects of particulate air pollution on blood pressure and heart rate:: The ultra study
    Ibald-Mulli, A
    Timonen, KL
    Lanki, T
    Buzorius, G
    Peters, A
    Heinrich, J
    Wölke, G
    Kreyling, WG
    de Hartog, J
    Hoek, G
    Pekkanen, J
    [J]. EPIDEMIOLOGY, 2001, 12 (04) : S73 - S73