Synthesis and antimicrobial activity of 3-substituted phenyl-5-(5′-substituted-2′-phenylindol-3′-yl)-1,2-diazoles and 3-substituted phenyl-5-(5'-substituted-2′-phenylindol-3′-yl)-isoxazoles

5-Substituted-2-phenylindol-3-carboxaldehydes (Ia-c) were condensed with substituted acetophenones (IIa-h) in ethylene glycol and catalytic amount of piperidine afforded 5-substituted-2-phenylindol-3-chalcones (IIIa-x). These compounds, on reaction with hydrazine hydrate in absolute alcohol and hydroxylamine hydrochloride in alcoholic sodium hydroxide yielded 3-substituted phenyl-5-(5'-substituted-2'-phenylindol-3'-yl)-1,2-diazoles (IVa-x) and 3-substituted phenyl-5-(5'-substituted-2-phenylindol-3'-yl) isoxazoles (Va-x), respectively. The newly sysnthesised compounds were characterised by their analytical and spectral data. All these compounds were screened for antimicrobial activity against S. aureus, E. coli, A. niger and C. albicans.