Antioxidative properties of ginsenoside Ro against UV-B-induced oxidative stress in human dermal fibroblasts

被引:14
|
作者
Kang, Hyun Ji [1 ]
Oh, Yuri [1 ]
Lee, Sihyeong [2 ]
Ryu, In Wang [1 ]
Kim, Kyunghoon [1 ]
Lim, Chang-Jin [2 ]
机构
[1] Kangwon Natl Univ, Dept Biol Sci, Chunchon, South Korea
[2] Kangwon Natl Univ, Dept Biochem, Chunchon, South Korea
关键词
ginsenoside Ro; UV-B radiation; oxidative stress; reactive oxygen species; glutathione; GLUTATHIONE; QUANTITIES;
D O I
10.1080/09168451.2015.1065170
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ginsenoside Ro (Ro), an oleanolic acid-type ginsenoside, exhibited suppressive activities on reactive oxygen species (ROS) and matrix metalloproteinase-2 (MMP-2) elevation in UV-B-irradiated fibroblasts. Ro could overcome the reduction of the total glutathione (GSH) contents in UV-B-irradiated fibroblasts. Ro could not interfere with cell viabilities in UV-B-irradiated fibroblasts. Collectively, Ro possesses a potential skin anti-photoaging property against UV-B radiation in fibroblasts.
引用
收藏
页码:2018 / 2021
页数:4
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