Thirty years of protein translocation into mitochondria: Unexpectedly complex and still puzzling

被引：88

作者：

Mokranjac, Deana

Neupert, Walter ^{[1
]}

机构：

[1] Univ Munich, Inst Physiol Chem, D-81377 Munich, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2009年 / 1793卷 / 01期

关键词：

Mitochondria; Protein translocases; Protein transport; Protein sorting; DISULFIDE RELAY SYSTEM; BETA-BARREL PROTEINS; TIM23 PREPROTEIN TRANSLOCASE; OUTER-MEMBRANE PROTEINS; TAIL-ANCHORED PROTEINS; TWIN-PORE TRANSLOCASE; C-TERMINAL DOMAIN; INTERMEMBRANE SPACE; INNER MEMBRANE; IMPORT MOTOR;

D O I：

10.1016/j.bbamcr.2008.06.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria are essential organelles of the eukaryotic cells that are made by expansion and division of preexisting mitochondria. The majority of their protein constituents are synthesized in the cytosol. They are transported into and put together within the organelle. This complex process is facilitated by several protein translocases. Here we summarize current knowledge on these sophisticated molecular machines that mediate recognition, transport across membranes and intramitochondrial sorting of many hundreds of mitochondrial proteins. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：33 / 41

页数：9

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