Nerve repair: Experimental and clinical evaluation of neurotrophic factors in peripheral nerve regeneration

被引：45
|
作者：
Johnson, Elizabeth O. [1 ]
Charchanti, Antonia [1 ]
Soucacos, Panayotis N. [2 ]
机构：
[1] Univ Ioannina, Sch Med, Dept Anat Histol & Embryol, GR-45110 Ioannina, Greece
[2] Univ Athens, Sch Med, Dept Orthopaed Surg, GR-11527 Athens, Greece
来源：
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED | 2008年 / 39卷
关键词：
NGF; BDNF; CNTF; GDNF; NT-3; Neurotrophin; Neurokines; Transforming growth factor;
D O I：
10.1016/j.injury.2008.06.015
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Neurotrophic factors are a family of polypeptides required for survival of discrete neuronal populations. In the normal state such factors are mostly synthesised by target tissues and are used for the viability of the nerve-cell bodies. After nerve injury, neurotrophic factors (NFs) are synthesised by non-neuronal (Schwann cells and fibroblasts) in the nerve trunk, and act to support the outgrowth of axons. NFs can be classified into three major groups: (1) neurotrophins; (2) neurokines; and (3) the transforming growth factor beta (TGF)-beta superfamily. (C) 2008 Published by Elsevier Ltd.
引用
收藏
页码：S37 / S42
页数：6
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