Effects of Anthocyanin Extracts from Bilberry (Vaccinium myrtillus L.) and Purple Potato (Solanum tuberosum L. var. 'Synkea Sakari') on the Plasma Metabolomic Profile of Zucker Diabetic Fatty Rats

被引：35

作者：

Chen, Kang ^{[1
]}

Wei, Xuetao ^{[2
]}

Zhang, Jian ^{[3
]}

Pariyani, Raghunath ^{[1
]}

Jokioja, Johanna ^{[1
]}

Kortesniemi, Maaria ^{[1
]}

Linderborg, Kaisa M. ^{[1
]}

Heinonen, Jari ^{[4
]}

Sainio, Tuomo ^{[4
]}

Zhang, Yumei ^{[3
]}

Yang, Baoru ^{[1
]}

机构：

[1] Univ Turku, Dept Biochem, Food Chem & Food Dev, FI-20014 Turku, Finland

[2] Peking Univ, Sch Publ Hlth, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100191, Peoples R China

[3] Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China

[4] Lappeenranta Univ Technol, Sch Engn Sci, FI-53850 Lappeenranta, Finland

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2020年 / 68卷 / 35期

基金：

芬兰科学院;

关键词：

acylated anthocyanins; nonacylated anthocyanins; Zucker diabetic fatty rats; type; 2; diabetes; NMR metabolomics; FLESHED SWEET-POTATO; INSULIN-RESISTANCE; NONACYLATED ANTHOCYANINS; ACYLATED ANTHOCYANINS; OXIDATIVE STRESS; AMINO-ACIDS; HYPERGLYCEMIA; BIOAVAILABILITY; BIOMARKERS; REVEALS;

D O I：

10.1021/acs.jafc.0c04125

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

This study compared the effects of the nonacylated and acylated anthocyanin-rich extracts on plasma metabolic profiles of Zucker diabetic fatty rats. The rats were fed with the nonacylated anthocyanin extract from bilberries (NAAB) or the acylated anthocyanin extract from purple potatoes (AAPP) at daily doses of 25 and 50 mg/kg body weight for 8 weeks. H-1 NMR metabolomics was used to study the changes in plasma metabolites. A reduced fasting plasma glucose level was seen in all anthocyanin-fed groups, especially in the groups fed with NAAB. Both NAAB and AAPP decreased the levels of branched-chain amino acids and improved lipid profiles. AAPP increased the glutamine/glutamate ratio and decreased the levels of glycerol and metabolites involved in glycolysis, suggesting improved insulin sensitivity, gluconeogenesis, and glycolysis. AAPP decreased the hepatic TBC1D1 and G6PC messenger RNA level, suggesting regulation of gluconeogenesis and lipogenesis. This study indicated that AAPP and NAAB affected the plasma metabolic profile of diabetic rats differently.

引用

页码：9436 / 9450

页数：15

共 3 条

[1] The preventive effects of dietary bilberry (Vaccinium myrtillus L.) extracts on oxidative stress induced by paraquat in rats
Nakasa, T
Takenaka, R
Okada, Y
Okinaka, O
JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI, 2006, 53 (01): : 1 - 7
[2] Preparation of Bed Reactor Using Brick Dust Immobilized Starch Phosphorhylase from Potato Tubers (Solanum tuberosum L. var. Kufri Badshah) for Production of Glucose-1-phosphate
Gupta, Supriya
Gupta, Sanjay Mohan
Kumar, Anil
NATIONAL ACADEMY SCIENCE LETTERS-INDIA, 2013, 36 (02): : 133 - 137
[3] Preparation of Bed Reactor Using Brick Dust Immobilized Starch Phosphorhylase from Potato Tubers (Solanum tuberosum L. var. Kufri Badshah) for Production of Glucose-1-phosphate
Supriya Gupta
Sanjay Mohan Gupta
Anil Kumar
National Academy Science Letters, 2013, 36 : 133 - 137

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