Mesenchymal stem cells: potential application for the treatment of hepatic cirrhosis

被引：31
|
作者：
Zhang, Yongting [1 ]
Li, Yuwen [2 ]
Zhang, Lili [1 ]
Li, Jun [1 ]
Zhu, Chuanlong [1 ]
机构：
[1] Nanjing Med Univ, Dept Infect Dis, Affiliated Hosp 1, Nanjing, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Dept Pediat, Affiliated Hosp 1, Nanjing, Jiangsu, Peoples R China
来源：
STEM CELL RESEARCH & THERAPY | 2018年 / 9卷
基金：
中国国家自然科学基金;
关键词：
Mesenchymal stem cells; Cirrhosis; Homing; DECOMPENSATED LIVER-CIRRHOSIS; UMBILICAL-CORD; BONE-MARROW; PROGENITOR CELLS; HEPATOCYTE TRANSPLANTATION; CHEMOTACTIC MIGRATION; STROMAL CELLS; REGENERATION; MICE; PROMOTES;
D O I：
10.1186/s13287-018-0814-4
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Nowadays, orthotopic liver transplantation is considered the most efficient approach to the end stage of chronic hepatic cirrhosis. Because of the limitations of orthotopic liver transplantation, stem cells are an attractive therapeutic option. Mesenchymal stem cells (MSCs) especially show promise as an alternative treatment for hepatic cirrhosis in animal models and during clinical trials. Nevertheless, the homing of transplanted MSCs to the liver occurs in limited numbers. Therefore, we review the strategies for enhancing the homing of MSCs, mainly via the delivery routes, optimizing cell culture conditions, stimulating the target sites, and genetic modification.
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页数：7
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