Gene Ontology Annotations and Resources

被引：404

作者：

Blake, J. A. ^{[2
]}

Dolan, M. ^{[2
]}

Drabkin, H. ^{[2
]}

Hill, D. P. ^{[2
]}

Ni, Li ^{[2
]}

Sitnikov, D. ^{[2
]}

Bridges, S. ^{[3
]}

Burgess, S. ^{[3
]}

Buza, T. ^{[3
]}

McCarthy, F. ^{[3
]}

Peddinti, D. ^{[3
]}

Pillai, L. ^{[3
]}

Carbon, S. ^{[4
]}

Dietze, H. ^{[4
]}

Ireland, A. ^{[4
]}

Lewis, S. E. ^{[4
]}

Mungall, C. J. ^{[4
]}

Gaudet, P. ^{[5
]}

Chisholm, R. L. ^{[5
]}

Fey, P. ^{[5
]}

Kibbe, W. A. ^{[5
]}

Basu, S. ^{[5
]}

Siegele, D. A. ^{[6
,7
]}

McIntosh, B. K. ^{[6
,7
]}

Renfro, D. P. ^{[6
,7
]}

Zweifel, A. E. ^{[6
,7
]}

Hu, J. C. ^{[6
,7
]}

Brown, N. H. ^{[8
,9
]}

Tweedie, S. ^{[8
,9
]}

Alam-Faruque, Y. ^{[10
,11
,12
]}

Apweiler, R. ^{[10
,11
,12
]}

Auchinchloss, A. ^{[10
,11
,12
]}

Axelsen, K. ^{[10
,11
,12
]}

Bely, B. ^{[10
,11
,12
]}

Blatter, M-C. ^{[10
,11
,12
]}

Bonilla, C. ^{[10
,11
,12
]}

Bougueleret, L. ^{[10
,11
,12
]}

Boutet, E. ^{[10
,11
,12
]}

Breuza, L. ^{[10
,11
,12
]}

Bridge, A. ^{[10
,11
,12
]}

Chan, W. M. ^{[10
,11
,12
]}

Chavali, G. ^{[10
,11
,12
]}

Coudert, E. ^{[10
,11
,12
]}

Dimmer, E. ^{[10
,11
,12
]}

Estreicher, A. ^{[10
,11
,12
]}

Famiglietti, L. ^{[10
,11
,12
]}

Feuermann, M. ^{[10
,11
,12
]}

Gos, A. ^{[10
,11
,12
]}

Gruaz-Gumowski, N. ^{[10
,11
,12
]}

Hieta, R. ^{[10
,11
,12
]}

机构：

[1] Stanford Univ, Dept Genet, SGD, Stanford, CA 94305 USA

[2] Jackson Lab, MGI, Bar Harbor, ME 04609 USA

[3] Mississippi State Univ, AgBase, Starkville, MS USA

[4] LBNL, BBOP, Berkeley, CA USA

[5] Northwestern Univ, DictyBase, Chicago, IL 60611 USA

[6] Texas A&M Univ, Dept Biochem & Biophys, EcoliWiki, College Stn, TX 77843 USA

[7] Texas A&M Univ, Dept Biol, EcoliWiki, College Stn, TX 77843 USA

[8] Univ Cambridge, Gurdon Inst, FlyBase, Cambridge, England

[9] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England

[10] UniProtKB EBI, Hinxton, Cambs, England

[11] Swiss Inst Bioinformat, SIB, Geneva, Switzerland

[12] PIR Georgetown, Washington, DC USA

[13] GO EBI, Hinxton, Cambs, England

[14] UCL, Inst Cardiovasc Sci, London, England

[15] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA

[16] EBI, InterPro, Hinxton, Cambs, England

[17] MTBBASE, Berlin, Germany

[18] Univ Cambridge, PomBase, Cambridge, England

[19] UCL, PomBase, London, England

[20] EBI, PomBase, Hinxton, Cambs, England

[21] Med Coll Wisconsin, RGD, Milwaukee, WI 53226 USA

[22] NYU, Sch Med, Dept Biochem, Reactome, New York, NY 10016 USA

[23] Carnegie Inst Sci, Dept Plant Biol, TAIR, Stanford, CA USA

[24] USC, Los Angeles, CA USA

[25] CALTECH, WormBase, Pasadena, CA 91125 USA

[26] Univ Oregon, ZFIN, Eugene, OR 97403 USA

来源：

NUCLEIC ACIDS RESEARCH | 2013年 / 41卷 / D1期

关键词：

D O I：

10.1093/nar/gks1050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Gene Ontology (GO) Consortium (GOC, http://www.geneontology.org) is a community-based bioinformatics resource that classifies gene product function through the use of structured, controlled vocabularies. Over the past year, the GOC has implemented several processes to increase the quantity, quality and specificity of GO annotations. First, the number of manual, literature-based annotations has grown at an increasing rate. Second, as a result of a new 'phylogenetic annotation' process, manually reviewed, homology-based annotations are becoming available for a broad range of species. Third, the quality of GO annotations has been improved through a streamlined process for, and automated quality checks of, GO annotations deposited by different annotation groups. Fourth, the consistency and correctness of the ontology itself has increased by using automated reasoning tools. Finally, the GO has been expanded not only to cover new areas of biology through focused interaction with experts, but also to capture greater specificity in all areas of the ontology using tools for adding new combinatorial terms. The GOC works closely with other ontology developers to support integrated use of terminologies. The GOC supports its user community through the use of e-mail lists, social media and web-based resources.

引用

页码：D530 / D535

页数：6

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