Effect of Oil-in-Water Submicron Emulsion Surface Charge on Oral Absorption of a Poorly Water-Soluble Drug in Rats

被引：2

作者：

Poullain-Termeau, Stephanie ^{[1
]}

Crauste-Manciet, Sylvie ^{[1
]}

Brossard, Denis ^{[1
]}

Muhamed, Saleh ^{[1
]}

Nicolaos, Georges ^{[1
]}

Farinotti, Robert ^{[2
]}

Barthelemy, Christine ^{[3
]}

Robert, Hugues ^{[3
]}

Odou, Pascal ^{[3
]}

机构：

[1] Univ Paris 05, Pharm Galen Lab, Fac Sci Pharmaceut & Biol, Paris, France

[2] Univ Paris 11, Fac Pharm, Lab Pharm Clin, UPRES 2706, F-92290 Chatenay Malabry, France

[3] Univ Lille 2, Pharm Galen & Biopharm Lab, Fac Pharm, Lille, France

来源：

DRUG DELIVERY | 2008年 / 15卷 / 08期

关键词：

Absorption; Conscious Rat; Griseofulvin; Oral Bioavailability; Stearylamine; Submicron o/w Emulsion; Surface Charge;

D O I：

10.1080/10717540802321792

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of oil-in-water submicron emulsion (SE) droplet surface charge on absolute bioavailability of a poorly water-soluble drug (griseofulvin, as model drug) after oral administration was studied in conscious rat. Positively, negatively, and neutrally charged SE were designed and characterized (size, polydispersity index, zeta potential, and pH). Three emulsion formulations, whose compositions included 40% oil phase and differed only in the nature of the emulsifying agent, were retained. Only the positively charged SE showed a higher area under the plasma concentration-time curve (AUC(0 ->infinity)) in comparison with the tablet and with the other SE.

引用

页码：503 / 514

页数：12

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