Insulin Upregulates PKM2 Expression But Inhibits its Activity to Promote Cancer Cell Metabolism

被引:0
|
作者
Iqbal, M. A. [1 ]
Bamezai, R. N. K. [1 ]
机构
[1] Jawaharlal Nehru Univ, Natl Ctr Appl Human Genet, Sch Life Sci, New Delhi 110067, India
关键词
D O I
10.1016/S0959-8049(12)71169-3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
503
引用
收藏
页码:S120 / S120
页数:1
相关论文
共 50 条
  • [1] Lapatinib Inhibits Breast Cancer Cell Proliferation by Influencing PKM2 Expression
    Guan, Mingxiu
    Tong, Yingna
    Guan, Minghua
    Liu, Xiaobin
    Wang, Meng
    Niu, Ruifang
    Zhang, Fei
    Dong, Dong
    Shao, Jie
    Zhou, Yunli
    TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2018, 17
  • [2] PKM2 contributes to cancer metabolism
    Wong, Nicholas
    Ojo, Diane
    Yan, Judy
    Tang, Damu
    CANCER LETTERS, 2015, 356 (02) : 184 - 191
  • [3] Activators of PKM2 in cancer metabolism
    Warner, Steven L.
    Carpenter, Kent J.
    Bearss, David J.
    FUTURE MEDICINAL CHEMISTRY, 2014, 6 (10) : 1167 - 1178
  • [4] Emerging roles of PKM2 in cell metabolism and cancer progression
    Luo, Weibo
    Semenza, Gregg L.
    TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2012, 23 (11): : 560 - 566
  • [5] Dual roles of PKM2 in cancer metabolism
    Wu, Songfang
    Le, Huangying
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2013, 45 (01) : 27 - 35
  • [6] PKM2, cancer metabolism, and the road ahead
    Dayton, Talya L.
    Jacks, Tyler
    Vander Heiden, Matthew G.
    EMBO REPORTS, 2016, 17 (12) : 1721 - 1730
  • [7] Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
    Hitosugi, Taro
    Kang, Sumin
    Heiden, Matthew G. Vander
    Chung, Tae-Wook
    Elf, Shannon
    Lythgoe, Katherine
    Dong, Shaozhong
    Lonial, Sagar
    Wang, Xu
    Chen, Georgia Z.
    Xie, Jianxin
    Gu, Ting-Lei
    Polakiewicz, Roberto D.
    Roesel, Johannes L.
    Boggon, Titus J.
    Khuri, Fadlo R.
    Gilliland, D. Gary
    Cantley, Lewis C.
    Kaufman, Jonathan
    Chen, Jing
    SCIENCE SIGNALING, 2009, 2 (97) : ra73
  • [8] Cryptanshinone Inhibits the Glycolysis and Inhibits Cell Migration Through PKM2/β-Catenin Axis in Breast Cancer
    Zhou, Jiefeng
    Su, Chih-Ming
    Chen, Hsin-An
    Du, Shicong
    Li, Chang-Wei
    Wu, Haoran
    Tsai, Shin-Han
    Yeh, Yu-Ting
    ONCOTARGETS AND THERAPY, 2020, 13 : 8629 - 8639
  • [9] Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer
    Chaneton, Barbara
    Gottlieb, Eyal
    TRENDS IN BIOCHEMICAL SCIENCES, 2012, 37 (08) : 309 - 316
  • [10] Changing the metabolism of cancer cells with PKM2 activators - a path to a cancer metabolism drug
    Behar, Vered
    Bohana-Kashtan, Osnat
    Shitrit, Alina
    Ben-Zeev, Efrat
    Konson, Alexander
    Ozeri, Rachel
    Kehat, Tzofit
    Mirilashvili, Sima
    Schutz, Nili C.
    Yacovan, Avihai
    Becker, Oren M.
    CANCER RESEARCH, 2012, 72