Conditional Reprogramming Inducing Clinical Cells Proliferation: New Research Tools in Tumor and Inflammatory-related Diseases

被引：4
|
作者：
Chai, Jie [1 ]
Han, Li [2 ]
Zhang, Jianbo [3 ]
Han, Dali [4 ]
Zou, Lei [1 ]
Zhu, Ze [5 ]
Zhao, Yulong [5 ]
Guo, Hongliang [1 ]
机构：
[1] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Gastrointestinal Surg, Jinan, Peoples R China
[2] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Internal Med Oncol, Jinan, Peoples R China
[3] Shandong Univ, Shandong Acad Med Sci, Shandong Canc Hosp, Dept Pathol, Jinan, Peoples R China
[4] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan, Peoples R China
[5] Tianjin Med Univ, Dept Pathogen Biol, Tianjin, Peoples R China
来源：
CURRENT PHARMACEUTICAL DESIGN | 2020年 / 26卷 / 22期
基金：
中国博士后科学基金;
关键词：
Tumor; inflammatory-related diseases; conditional reprogramming (CR); drugs screening; cell lines; proliferative; PLURIPOTENT STEM-CELLS; ROCK INHIBITOR;
D O I：
10.2174/1381612826666200316155252
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In the era of precision medicine, establishing a patient-derived cell model is crucial, whether in vitro or in vivo. Compared to the traditional cell lines, patient-derived primary cells represent precise genetic features from specific patients, but poor proliferative activity of human primary cells restricts their popular application. Conditional reprogramming (CR) is a new cell culture technique to achieve rapid growth of patient-derived cells in vitro, making it possible to identify the individual difference and screen drugs sensitivity. In this review, we will summarize the application and limitation of CR in tumor and inflammatory-related diseases, indicating the prospect of this technique for preclinical research.
引用
收藏
页码：2657 / 2660
页数：4
相关论文
共 20 条
  • [1] Research progress of hexokinase 2 in inflammatory-related diseases and its inhibitors
    Chen, Jinxia
    Li, Guirong
    Sun, Dejuan
    Li, Hua
    Chen, Lixia
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 264
  • [2] Cynanchum paniculatum and Its Major Active Constituents for Inflammatory-Related Diseases: A Review of Traditional Use, Multiple Pathway Modulations, and Clinical Applications
    Chen, Jing-xian
    Cheng, Chien-shan
    Chen, Jie
    Lv, Ling-ling
    Chen, Zi-jie
    Chen, Chuan
    Zheng, Lan
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2020, 2020
  • [3] Enteric Glial Cells: A New Frontier in Neurogastroenterology and Clinical Target for Inflammatory Bowel Diseases
    Ochoa-Cortes, Fernando
    Turco, Fabio
    Linan-Rico, Andromeda
    Soghomonyan, Suren
    Whitaker, Emmett
    Wehner, Sven
    Cuomo, Rosario
    Christofi, Fievos L.
    INFLAMMATORY BOWEL DISEASES, 2016, 22 (02) : 433 - 449
  • [4] Regulatory B cells in human inflammatory and autoimmune diseases: from mouse models to clinical research
    Miyagaki, Tomomitsu
    Fujimoto, Manabu
    Sato, Shinichi
    INTERNATIONAL IMMUNOLOGY, 2015, 27 (10) : 495 - 504
  • [5] Research on Cell Aging Based on Reprogramming Senescent Cells by Inhibiting Pro-Inflammatory TNF/Edn1 Pathway as a Potential Treatment of Age-Related Diseases
    Cui, Siwen
    Wang, Virgia
    2022 6TH INTERNATIONAL CONFERENCE ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS (ICCBB 2022), 2022, : 27 - 34
  • [6] Clinical Research into Central Nervous System Inflammatory Demyelinating Diseases Related to COVID-19 Vaccines
    Cheng, Mei-Yun
    Ho, Hsuan-Chen
    Hsu, Jung-Lung
    Wang, Yi
    Chen, Linyi
    Lim, Siew-Na
    Liao, Ming-Feng
    Ro, Long-Sun
    DISEASES, 2024, 12 (03)
  • [7] Tumor necrosis factor-related apoptosis-inducing ligand-mediated proliferation of tumor cells with receptor-proximal apoptosis defects
    Baader, E
    Toloczko, A
    Fuchs, U
    Schmid, I
    Beltinger, C
    Ehrhardt, H
    Debatin, KM
    Jeremias, I
    CANCER RESEARCH, 2005, 65 (17) : 7888 - 7895
  • [8] Tumor necrosis factor-related apoptosis-inducing ligand inhibits proliferation and induces apoptosis of prostate and bladder cancer cells
    Hao, Lin
    Zhao, Yan
    Li, Zhi-Gang
    He, Hou-Guang
    Liang, Qing
    Zhang, Zhi-Guo
    Shi, Zhen-Duo
    Zhang, Pei-Ying
    Han, Cong-Hui
    ONCOLOGY LETTERS, 2017, 13 (05) : 3638 - 3640
  • [9] Tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis and inflammatory gene expression in human endothelial cells
    Li, JH
    Kirkiles-Smith, NC
    McNiff, JM
    Pober, JS
    FASEB JOURNAL, 2003, 17 (07): : C136 - C136
  • [10] Immune cells and their related genes provide a new perspective on the common pathogenesis of ankylosing spondylitis and inflammatory bowel diseases
    Ding, Yimei
    Yang, Yue
    Xue, Luan
    FRONTIERS IN IMMUNOLOGY, 2023, 14
12