Immunogenetic Markers Definition in Latvian Patients with Lyme Borreliosis and Lyme Neuroborreliosis

被引：1
|
作者：
Kovalchuka, Lilija [1 ]
Cvetkova, Svetlana [1 ]
Trofimova, Julija [1 ]
Eglite, Jelena [2 ]
Gintere, Sandra [3 ]
Lucenko, Irina [4 ]
Oczko-Grzesik, Barbara [5 ]
Viksna, Ludmila [6 ]
Krumina, Angelika [1 ,6 ]
机构：
[1] Inst Food Safety Anim Hlth & Environm BIOR, LV-1076 Riga, Latvia
[2] Riga Stradins Univ, Lab Clin Immunol & Immunogenet, LV-1067 Riga, Latvia
[3] Riga Stradins Univ, Dept Family Med, LV-1067 Riga, Latvia
[4] Ctr Dis Prevent & Control Latvia, LV-1005 Riga, Latvia
[5] Med Univ Silesia, Dept Infect Dis, PL-40055 Katowice, Poland
[6] Riga Stradins Univ, Dept Infectol & Dermatol, LV-1006 Riga, Latvia
来源：
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2016年 / 13卷 / 12期
关键词：
Borrelia burgdorferi; Lyme borreliosis; Lyme neuroborreliosis; immunogenetic markers; HLA-DRB1; IXODES-RICINUS TICKS; BURGDORFERI SENSU-LATO; HLA-DR; GEOGRAPHICAL-DISTRIBUTION; BORNE PATHOGENS; QUESTING TICKS; DISEASE; INFECTION; ASSOCIATIONS; MOLECULES;
D O I：
10.3390/ijerph13121194
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction-sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles. The allele -DRB1*11(05), -DRB1*14(06) and -DRB1*13(06) were significantly more frequent in controls. In-group with Lyme neuroborreliosis differences were found for the -DRB1*07 and -DRB1*04 alleles, but only HLA-DRB1*07 allele was statistically significant after Bonferroni correction and associated with Lyme neuroborreliosis in Latvian patients.
引用
收藏
页数：11
相关论文
共 50 条
  • [1] Lyme borreliosis and Lyme neuroborreliosis - an update
    Dersch, Rick
    Fingerle, Volker
    [J]. DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 2021, 146 (11) : 728 - 732
  • [2] Epidemiology of Lyme borreliosis and neuroborreliosis in France
    Blanc, F.
    [J]. REVUE NEUROLOGIQUE, 2009, 165 (8-9) : 694 - 701
  • [3] Complement activation in individuals with previous subclinical Lyme borreliosis and patients with previous Lyme neuroborreliosis
    Carlsson, Hanna
    Sandholm, Kerstin
    Haddish, Haben Woldu
    Brudin, Lars
    Ekdahl, Kristina Nilsson
    Tjernberg, Ivar
    [J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2020, 39 (05) : 855 - 862
  • [4] Complement activation in individuals with previous subclinical Lyme borreliosis and patients with previous Lyme neuroborreliosis
    Hanna Carlsson
    Kerstin Sandholm
    Haben Woldu Haddish
    Lars Brudin
    Kristina Nilsson Ekdahl
    Ivar Tjernberg
    [J]. European Journal of Clinical Microbiology & Infectious Diseases, 2020, 39 : 855 - 862
  • [5] Complement activation in asymptomatic Lyme borreliosis and neuroborreliosis
    Carlsson, Hanna
    Sandholm, Kerstin
    Tjernberg, Ivar
    Ekdahl, Kristina N.
    [J]. MOLECULAR IMMUNOLOGY, 2015, 67 (01) : 128 - 128
  • [6] Associations of HLA DR and DQ molecules with Lyme borreliosis in Latvian patients
    Kovalchuka L.
    Eglite J.
    Lucenko I.
    Zalite M.
    Viksna L.
    Krumia A.
    [J]. BMC Research Notes, 5 (1)
  • [7] LYME ARTHRITIS - IMMUNOLOGICAL AND IMMUNOGENETIC MARKERS
    STEERE, AC
    GIBOFSKY, A
    HARDIN, JA
    WINCHESTER, RJ
    MALAWISTA, SE
    [J]. ARTHRITIS AND RHEUMATISM, 1979, 22 (06): : 662 - 663
  • [8] Tired of Lyme borreliosis Lyme borreliosis in the Netherlands
    Coumou, J.
    van der Poll, T.
    Speelman, P.
    Hovius, J. W. R.
    [J]. NETHERLANDS JOURNAL OF MEDICINE, 2011, 69 (03): : 101 - 111
  • [9] Lyme disease (Lyme borreliosis)
    Yanagihara, Y
    Masuzawa, T
    [J]. FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 1997, 18 (04): : 249 - 261
  • [10] Neuroborreliosis in patients hospitalised for Lyme borreliosis in the Czech Republic in 2003-2013
    Kriz, B.
    Maly, M.
    Daniel, M.
    [J]. EPIDEMIOLOGIE MIKROBIOLOGIE IMUNOLOGIE, 2017, 66 (03): : 115 - 123
12345