Epigenetic therapy of cancer: past, present and future

被引：1019
|
作者：
Yoo, CB
Jones, PA
机构：
[1] Univ So Calif, USC Norris Comprehens Canc Ctr, Dept Urol, Los Angeles, CA 90089 USA
[2] Univ So Calif, Dept Biochem & Mol Biol, Keck Sch Med, Los Angeles, CA 90089 USA
来源：
NATURE REVIEWS DRUG DISCOVERY | 2006年 / 5卷 / 01期
关键词：
D O I：
10.1038/nrd1930
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The initiation and progression of cancer is controlled by both genetic and epigenetic events. Unlike genetic alterations, which are almost impossible to reverse, epigenetic aberrations are potentially reversible, allowing the malignant cell population to revert to a more normal state. With the advent of numerous drugs that target specific enzymes involved in the epigenetic regulation of gene expression, the utilization of epigenetic targets is emerging as an effective and valuable approach to chemotherapy as well as chemoprevention of cancer.
引用
收藏
页码：37 / 50
页数：14
相关论文
共 50 条
  • [1] Epigenetic therapy of cancer: past, present and future
    Christine B. Yoo
    Peter A. Jones
    [J]. Nature Reviews Drug Discovery, 2006, 5 : 37 - 50
  • [2] Erratum: Epigenetic therapy of cancer: past, present and future
    Christine B. Yoo
    Peter A. Jones
    [J]. Nature Reviews Drug Discovery, 2006, 5 : 170 - 170
  • [3] Epigenetic therapy of cancer: past, present and future (vol 5, pg 37, 2006)
    Yoo, CB
    Jones, PA
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (02) : 170 - 170
  • [4] Adjuvant therapy of cancer: Past, present, and future
    Salmon, SE
    [J]. ADJUVANT THERAPY OF CANCER VIII, 1997, 8 : 3 - 8
  • [5] CANCER-THERAPY - PAST, PRESENT AND FUTURE
    AMER, MH
    [J]. ANNALS OF SAUDI MEDICINE, 1986, 6 (01) : 1 - 2
  • [6] The past, present and future of conversion therapy for liver cancer
    Song, Tianqiang
    Lang, Mengran
    Ren, Shaohua
    Gan, Leijuan
    Lu, Wei
    [J]. AMERICAN JOURNAL OF CANCER RESEARCH, 2021, 11 (10): : 4711 - 4724
  • [7] Cell Transfer Therapy for Cancer: Past, Present, and Future
    Qian, Xiaoling
    Wang, Xian
    Jin, Hongchuan
    [J]. JOURNAL OF IMMUNOLOGY RESEARCH, 2014, 2014 : 525913
  • [8] Natural Products in Cancer Therapy: Past, Present and Future
    Huang, Min
    Lu, Jin-Jian
    Ding, Jian
    [J]. NATURAL PRODUCTS AND BIOPROSPECTING, 2021, 11 (01) : 5 - 13
  • [9] Natural Products in Cancer Therapy: Past, Present and Future
    Min Huang
    Jin-Jian Lu
    Jian Ding
    [J]. Natural Products and Bioprospecting, 2021, 11 : 5 - 13
  • [10] Gene Therapy for Cancer Treatment: Past, Present and Future
    Cross, Deanna
    Burmester, James K.
    [J]. CLINICAL MEDICINE & RESEARCH, 2006, 4 (03) : 218 - 227
12345