Hereditary ovarian cancer

被引：0
|
作者：
Langston, AA [1 ]
Ostrander, EA [1 ]
机构：
[1] FRED HUTCHINSON CANC RES CTR, DIV CLIN RES, SEATTLE, WA 98104 USA
来源：
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY | 1997年 / 9卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Ovarian cancer has been described in association with three autosomal dominant syndromes: familial site-specific ovarian cancer, familial breast and ovarian cancer, and the hereditary nonpolyposis colon cancer syndrome. It appears that most breast-ovarian and site-specific ovarian cancer families are explained by mutations in the BRCA1 tumor suppressor gene. Other genes associated with inherited susceptibility to ovarian cancer include BRCA2, p53, and the DNA mismatch repair genes.
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页码：3 / 7
页数：5
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