Making sense of nonsense

被引：10
|
作者：
Hentze, Matthias W. [1 ]
Izaurralde, Elisa [2 ]
机构：
[1] European Mol Biol Lab, Heidelberg, Germany
[2] Max Planck Inst Dev Biol, Dept Biochem, Tubingen, Germany
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2013年 / 20卷 / 06期
关键词：
MESSENGER-RNA DECAY; CAP-BINDING COMPLEX; EUKARYOTIC TRANSLATION INITIATION; EXON JUNCTION COMPLEX; MAMMALIAN-CELLS; NUCLEAR; PROVIDES; PROTEIN; CBP80; UPF1;
D O I：
10.1038/nsmb.2601
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eukaryotic mRNAs containing nonsense codons are degraded by nonsense-mediated mRNA decay (NMD). In humans, NMD was proposed to act exclusively on newly synthesized mRNA during a 'pioneer round' of translation, when mRNA is associated with the nuclear cap-binding complex (CBC). Two reports now challenge this view, revealing that NMD is independent of whether CBC or the cytoplasmic cap-binding protein (eIF4E) promotes translation and can occur later in an mRNA's life.
引用
收藏
页码：651 / 653
页数：3
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