Impaired Awareness of Deficits in Alzheimer's Disease: The Role of Everyday Executive Dysfunction

被引:42
|
作者
Amanzio, Martina [1 ,2 ,3 ]
Vase, Lene [4 ,5 ]
Leotta, Daniela [6 ]
Miceli, Renato [1 ,2 ]
Palermo, Sara [1 ,2 ]
Geminiani, Giuliano [1 ,2 ,3 ]
机构
[1] Univ Turin, Dept Psychol, I-10123 Turin, Italy
[2] Univ Turin, NIT, I-10123 Turin, Italy
[3] Natl Inst Neurosci, Turin, Italy
[4] Aarhus Univ, Dept Psychiat & Behav Sci, Aarhus C, Denmark
[5] Aarhus Univ Hosp, Danish Pain Res Ctr, Aarhus C, Denmark
[6] Martini Hosp, Alzheimer Assessment Unit, UVA & Neurol Unit, Turin, Italy
关键词
Impaired awareness of cognitive deficits; Impaired awareness of behavioral deficits; Executive functions; Behavioral Assessment of the Dysexecutive Syndrome; Principal components analysis; Multiple regression analysis; MILD COGNITIVE IMPAIRMENT; MINI-MENTAL-STATE; MEMORY DEFICIT; RATING-SCALE; PSYCHIATRIC-SYMPTOMS; STRATEGY APPLICATION; CLINICAL-DIAGNOSIS; ANOSOGNOSIA; UNAWARENESS; AD;
D O I
10.1017/S1355617712000896
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The present study analyzed the awareness of deficits in 117 mild Alzheimer's disease participants. Since few studies have examined the cognitive and behavioral domains of reduced awareness in detail, we performed a domain-specific assessment using the Awareness of deficit Questionnaire - Dementia scale with the novel aim of describing the relationship with everyday executive dysfunction. Through the use of the subtests of the Behavioral Assessment of the Dysexecutive Syndrome, we hypothesized that executive cognitive functions may play an important role in the reduced awareness of deficits. We also considered other variables of interest to provide a novel comprehensive explanation of this phenomenon. Our first approach to the study was a factor analysis considering the role of these variables in the awareness of deficits; subsequently, regression analysis models were used to define which variables were associated with a reduction of awareness in cognitive and behavioral domains. In particular, the factors retained from the factor analysis, in terms of inhibition, self-monitoring, set-shifting, and mood orientation changes, appear to be important skills for awareness of instrumental activities of daily living (R-2 = .32). We also found hypo manic mood orientation and a tendency through apathy to be prominent indications of reduced behavioral awareness (R-2 = .13). (JINS, 2013, 19, 63-72)
引用
收藏
页码:63 / 72
页数:10
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