A MATHEMATICAL MODEL FOR WITHIN-HOST TOXOPLASMA GONDII INVASION DYNAMICS

被引：12

作者：

Sullivan, Adam ^{[1
]}

Agusto, Folashade ^{[2
]}

Bewick, Sharon ^{[3
]}

Su, Chunlei ^{[4
]}

Lenhart, Suzanne ^{[5
]}

Zhao, Xiaopeng ^{[1
]}

机构：

[1] Univ Tennessee, Dept Mech Aerosp & Biomed Engn, Knoxville, TN 37996 USA

[2] Austin Peay State Univ, Dept Math & Stat, Clarksville, TN 37044 USA

[3] Univ Tennessee, Natl Inst Math & Biol Synth, Knoxville, TN 37996 USA

[4] Univ Tennessee, Dept Microbiol, Knoxville, TN 37996 USA

[5] Univ Tennessee, Dept Math, Knoxville, TN 37996 USA

来源：

MATHEMATICAL BIOSCIENCES AND ENGINEERING | 2012年 / 9卷 / 03期

基金：

美国国家科学基金会;

关键词：

Toxoplasma gondii; stage conversion; parasite infection; within-host invasion; intra-host dynamics; TRANSMISSION DYNAMICS; DISEASE; BRADYZOITES; INFECTION;

D O I：

10.3934/mbe.2012.9.647

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Toxoplasma gondii (T. gondii) is a protozoan parasite that infects a wide range of intermediate hosts, including all mammals and birds. Up to 20% of the human population in the US and 30% in the world are chronically infected. This paper presents a mathematical model to describe intra-host dynamics of T. gondii infection. The model considers the invasion process, egress kinetics, interconversion between fast-replicating tachyzoite stage and slowly replicating bradyzoite stage, as well as the host's immune response. Analytical and numerical studies of the model can help to understand the influences of various parameters to the transient and steady-state dynamics of the disease infection.

引用

页码：647 / 662

页数：16

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