Anti-diabetic activity peptides from albumin against α-glucosidase and α-amylase

被引：185
|
作者：
Yu, Zhipeng [1 ]
Yin, Yongguang [1 ]
Zhao, Wenzhu [1 ]
Liu, Jingbo [1 ]
Chen, Feng [2 ]
机构：
[1] Jilin Univ, Sch Biol & Agr Engn, Changchun 130022, Peoples R China
[2] Clemson Univ, Dept Food Sci & Human Nutr, Clemson, SC 29634 USA
来源：
FOOD CHEMISTRY | 2012年 / 135卷 / 03期
关键词：
Anti-diabetic activity; Peptides; Diabetes; Glucosidase inhibitor; Amylase inhibitor; Hen egg; Albumin; EGG-WHITE; INHIBITORY-ACTIVITIES; BIOACTIVITIES; ANTIOXIDANT; HYDROLYSATE; EXTRACT; LEAVES; CELLS; RATS;
D O I：
10.1016/j.foodchem.2012.06.088
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The objectives of this study were to identify novel peptides from albumin, and to evaluate and validate the anti-diabetic activity of peptides against alpha-glucosidase and alpha-amylase. In the research, albumin hydrolysate was purified and identified, tandem MS was adapted to characterise the amino acid sequences of peptides from the hydrolysate. In addition, anti-diabetic effects of the peptides with alpha-glucosidase and alpha-amylase inhibitory activity have been performed. The present work found eight novel peptides from albumin. Results also suggested that peptide KLPGF had alpha-glucosidase inhibitory activity with an IC50 of 59.5 +/- 5.7 mu mol l(-1) and alpha-amylase inhibitory activity with an IC50 of 120.0 +/- 4.0 mu mol l(-1). In conclusion, the results revealed that the peptide KLPGF was a potential anti-diabetic inhibitor. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2078 / 2085
页数：8
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