Alternative synthesis of ( plus /-) Cherylline dimethyl ether

被引：8
|
作者：
Kurangi, Reshma [1 ]
Kinalekar, Suvidha [1 ]
Tilve, Santosh [1 ]
Kirtany, Janardan [1 ]
机构：
[1] Goa Univ, Dept Chem, Taleigao Plateau 403206, Goa, India
来源：
ARKIVOC | 2008年
关键词：
Michael reaction; Curtius reaction; Pictet-Spangler cyclization; tetrahydroisoquinoline;
D O I：
10.3998/ark.5550190.0009.c27
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An alternative synthesis of isoquinoline alkaloid (+/-) cherylline dimethyl ether is reported. The steps involved are acid-catalyzed Michael addition of veratrole to p-methoxycinnamic acid, Curtius rearrangement, reduction of isocyanate intermediate followed by Pictet-Spangler cyclization.
引用
收藏
页码：256 / 261
页数：6
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