Adverse effects of intradermal allogeneic lymphocyte immunotherapy: acute reactions and role of autoimmunity

被引:32
|
作者
Kling, C [1 ]
Steinmann, J [1 ]
Westphal, E [1 ]
Magez, J [1 ]
Kabelitz, D [1 ]
机构
[1] Univ Hosp Schleswig Holstein, Inst Immunol, D-24105 Kiel, Germany
关键词
allogeneic lymphocyte immunotherapy; autoimmunity; graft versus host disease; HIV; Rhesus haemolytic disease;
D O I
10.1093/humrep/dei316
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
BACKGROUND: Immunotherapy with allogeneic lymphocytes was introduced as a therapeutic option for selected infertile couples in different centres worldwide 20 years ago. It has been suggested for other indications as well, e.g. for pregnant women at risk of a child with Rhesus-D haemolytic disease, or as a vaccine which might reduce the receptiveness for HIV-1 infection. Here we report on our experience on adverse side-effects of intradermal lymphocyte immunotherapy (LIT) for infertile couples using partner's lymphocytes. METHODS: Prospective 4 week follow-up of all couples from 2000 to 2003 for acute reactions (feedback 2587/3246, 83%). All couples treated between 1996 and 2002 received questionnaires after 2-3 years (feedback 1914/3041, 63%). RESULTS: Local reactions predominantly consisted of redness and itching for similar to 2 weeks. Systemic reactions could be attributed to LIT in 6-8%. Blisters at the injection sites were characteristic of LIT but not dependent on the HLA class I mismatch status between cell donor and host. The incidence of autoimmune disease was 0.1%. Four patients developed thromboembolism in pregnancy which was not ascribed to antiphospholipid syndrome. CONCLUSIONS: Acute side-effects are comparable to those reported after intradermal vaccination for infectious diseases. Specific risks for anaphylaxis, autoimmune or graft versus host disease were not detected.
引用
收藏
页码:429 / 435
页数:7
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共 36 条
  • [1] Adverse effects of intradermal allogeneic lymphocyte immunotherapy: acute reactions and role of autoimmunity (vol 21, pg 429, 2006)
    Kling, C.
    Steinmann, J.
    Westphal, E.
    Magez, J.
    Kabelitz, D.
    [J]. HUMAN REPRODUCTION, 2006, 21 (08) : 2198 - 2198
  • [2] Acute adverse effects of allogeneic lymphocyte immunization
    Kling, C
    Steinmann, J
    Magez, J
    Westphal, E
    Kabelitz, D
    [J]. GEBURTSHILFE UND FRAUENHEILKUNDE, 2005, 65 (04) : 404 - 413
  • [3] Adverse reactions to intradermal morphine and the effects of vehicle preservatives
    Wagner, PJ
    Smith, M
    Stout, RG
    Hussein, M
    Pascale, V
    Brull, SJ
    Silverman, DG
    [J]. ANESTHESIA AND ANALGESIA, 1997, 84 : S345 - S345
  • [4] Transfusion-related risks of intradermal allogeneic lymphocyte immunotherapy: Single cases in a large cohort and review of the literature
    Kling, Christiane
    Steinmann, Joerg
    Flesch, Brigitte
    Westphal, Eckhard
    Kabelitz, Dieter
    [J]. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2006, 56 (03) : 157 - 171
  • [5] Adverse drug reactions following lymphocyte immunotherapy for the treatment of infertility: A retrospective study
    Eidizadeh, Abass
    Papert, Susanne
    Valk, Jakob
    Pollok-Kopp, Beatrix
    Goldmann, Monika
    Riggert, Joachim
    Moltrecht, Rudiger
    Legler, Tobias J.
    [J]. JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2022, 48 (10) : 2571 - 2582
  • [6] Effects of decitabine on allogeneic immune reactions of donor lymphocyte infusion via activation of dendritic cells
    Yong-Rim Kwon
    Hye Joung Kim
    Min-Jung Sohn
    Ji-Young Lim
    Kyung-Shin Park
    Seok Lee
    Nack-Gyun Chung
    Dae-Chul Jeong
    Chang-Ki Min
    Yoo-Jin Kim
    [J]. Experimental Hematology & Oncology, 9
  • [7] ALLOGENEIC SUPPRESSIVE EFFECTS OF PREGNANCY SERA ON MONOCYTES OF RESPONDING CELLS IN HUMAN MIXED LYMPHOCYTE REACTIONS
    NIEDA, M
    JUJI, T
    IMAO, S
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (04): : 1477 - 1484
  • [8] Effects of decitabine on allogeneic immune reactions of donor lymphocyte infusion via activation of dendritic cells
    Kwon, Yong-Rim
    Kim, Hye Joung
    Sohn, Min-Jung
    Lim, Ji-Young
    Park, Kyung-Shin
    Lee, Seok
    Chung, Nack-Gyun
    Jeong, Dae-Chul
    Min, Chang-Ki
    Kim, Yoo-Jin
    [J]. EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2020, 9 (01)
  • [9] Role of allogeneic haematopoietic stem cell transplantation in the treatment of adult acute lymphoblastic leukaemia in the era of immunotherapy
    Sun, Wei
    Huang, Xiaojun
    [J]. CHINESE MEDICAL JOURNAL, 2022, 135 (08) : 890 - 900
  • [10] Role of allogeneic haematopoietic stem cell transplantation in the treatment of adult acute lymphoblastic leukaemia in the era of immunotherapy
    Sun Wei
    Huang Xiaojun
    [J]. 中华医学杂志(英文版), 2022, (08) : 890 - 900