COX-2 INHIBITORS FROM STEM BARK OF BAUHINIA RUFESCENS LAM. (FABACEAE)

被引：0
|
作者：
Muhammad, Aminu [1 ]
Sirat, Hasnah Mohd [1 ]
机构：
[1] Univ Teknol Malaysia, Fac Sci, Dept Chem, Skudai 81310, Johor Bahru, Malaysia
来源：
EXCLI JOURNAL | 2013年 / 12卷
关键词：
COX-2; Bauhinia rufescens; phytochemicals; MEDICINAL-PLANTS; CYCLOOXYGENASE; ANTIFUNGAL; CYCLITOLS;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Chemical investigation of the stem bark of Bauhinia rufescens resulted in the isolation of a new cyanoglucoside and menisdaurin from methanol extract and oxepin from petroleum ether extract. The isolated compounds were tested for their anti-inflammatory potentials based on the cyclooxygenase-2 enzyme (COX-2) model. Cyanoglucoside exhibited the highest activity among the compounds with an inhibition activity of 49.34 % at 100 mu M (IC50 0.46 mu M) compared to the positive control, indomethacin (79.20 %, IC50 0.24 mu M).
引用
收藏
页码：824 / 830
页数：7
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