Survey of antibiotic use of individuals visiting public healthcare facilities in Indonesia

被引:69
|
作者
Hadi, Usman [1 ]
Duerink, D. Offra [2 ]
Lestari, Endang Sri [3 ]
Nagelkerke, Nico J. [4 ]
Werter, Susanne [5 ]
Keuter, Monique [5 ]
Suwandojo, Eddy [1 ]
Rahardjo, Eddy [6 ]
van den Broek, Peterhans [2 ]
Gyssens, Inge C. [7 ,8 ,9 ,10 ]
机构
[1] Airlangga Univ, Sch Med, Dr Soetomo Hosp, Dept Internal Med, Surabaya 60118, Indonesia
[2] Leiden Univ, Med Ctr, Dept Infect Dis, Leiden, Netherlands
[3] Diponegoro Univ, Sch Med, Dr Kariadi Hosp, Dept Clin Microbiol, Semarang, Indonesia
[4] United Arab Emirates Univ, Dept Community Med, Al Ain, U Arab Emirates
[5] Radboud Univ Nijmegen, Med Ctr, Nijmegen Univ Ctr Infect Dis Int Hlth, Dept Internal Med, NL-6525 ED Nijmegen, Netherlands
[6] Airlangga Univ, Sch Med, Dr Soetomo Hosp, Dept Anaesthesiol, Surabaya, Indonesia
[7] Erasmus Univ, Med Ctr, Dept Internal Med, Rotterdam, Netherlands
[8] Erasmus Univ, Med Ctr, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
[9] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands
[10] Radboud Univ Nijmegen, Med Ctr, Nijmegen Univ Ctr Infect Dis, Dept Internal Med, NL-6525 ED Nijmegen, Netherlands
关键词
Antibiotic policy; Antimicrobial agents; Resistance; Community; Self-medication;
D O I
10.1016/j.ijid.2008.01.002
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Objectives: To estimate the antibiotic use of individuals visiting public healthcare facilities in Indonesia and to identify determinants of use against a background of high resistance rates. Methods: Patients on admission to hospital (group A), visiting a primary health center (group B), and healthy relatives (group C) were included in the study. A questionnaire on demographic, socioeconomic, and healthcare-related items including health complaints and consumption of antibiotics was used. Logistic regression was performed to determine the co-variables of antibiotic use. Results: Of 2996 individuals interviewed, 486 (16%) had taken an antibiotic. Compared to group C (7% consumption), groups B and A exhibited a three-fold and four-fold higher use of antibiotics, respectively. Respiratory (80%) and gastrointestinal (13%) symptoms were most frequent. Aminopenicillins and tetracyclines accounted for 80% of the prescribed antibiotics. Similar antibiotics were self-medicated (17% of users). Age less than 18 years and health insurance were independent determinants of antibiotic use. Urban provenance, being adult, male, and having no health insurance were independent determinants of self-medication. Conclusions: In addition to health complaints, other factors determined antibiotic consumption. In view of the likely viral origin of respiratory complaints and the resistance of intestinal pathogens, most antibiotic use was probably unnecessary or ineffective. Future interventions should be directed towards healthcare providers. (C) 2008 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:622 / 629
页数:8
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