Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl) ethylenediamine]dichloroplatinum(II) act on the hormone-sensitive, murine breast cancer as a biological response modifier?: Part 1:: The MXT-M-3.2 breast cancer stimulates the growth of an identical second graft;: [Meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) inhibits this process

被引：0

作者：

Schlemmer, R ^{[1
]}

Spruss, T ^{[1
]}

Bernhardt, G ^{[1
]}

Schönenberger, H ^{[1
]}

机构：

[1] Univ Regensburg, Inst Pharm, Lehrstuhl Pharmazeut Chem 2, D-93040 Regensburg, Germany

来源：

ARCHIV DER PHARMAZIE | 2000年 / 333卷 / 2-3期

关键词：

MXT-M-3.2 breast cancer; graft-graft interaction; tumor growth stimulation; meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II);

D O I：

10.1002/(SICI)1521-4184(200002)333:2/3<69::AID-ARDP69>3.0.CO;2-D

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The MXT-M-3.2 breast cancer implanted into female B6D3F(1) mice accelerates the growth of an identical second tumor. This process is inhibited by [meso-1,2-bis(2,6-dichloro-4-hydroxyphenl)ethylenediamine]dichloroplatinum(II). The possible modes of action of this compound as a biological response modifier are discussed.

引用

页码：69 / 71

页数：3

共 20 条

[1] Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]-dichloroplatinum(II) act on the hormone-sensitive, murine breast cancer as a biological response modifier?: Part II.: Studies on the influence of [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) on the specific immune defense in MXT-M-3,2 breast cancer bearing mice
Schlemmer, R
Spruss, T
Bernhardt, G
Schönenberger, H
ARCHIV DER PHARMAZIE, 2000, 333 (12) : 397 - 403
[2] [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]sulfatoplatinum(II) -: Pharmacokinetic studies
Bernhardt, G
Koch, M
Spruss, T
Gust, R
Krauser, R
Schlemmer, R
Hollstein, M
Lux, F
Schönenberger, H
ARCHIV DER PHARMAZIE, 1999, 332 (06) : 195 - 200
[3] REGIOSPECIFIC INCORPORATION OF ISOTOPIC HYDROGEN INTO MESO[1,2-BIS(2,6-DICHLORO-4-HYDROXYPHENYL)ETHYLENEDIAMINE]DICHLOROPLATINUM(II)
BEDNARSKI, PJ
SCHONENBERGER, H
APPLIED RADIATION AND ISOTOPES, 1988, 39 (06) : 571 - 571
[4] [meso-1,2-Bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a compound with a specific activity on hormone-sensitive breast cancers -: Evidence for a diethylstilbestrol-like mode of action
Schlemmer, R
Spruss, T
Bernhardt, G
Schönenberger, H
ARCHIV DER PHARMAZIE, 1999, 332 (02) : 59 - 69
[5] [MESO-1,2-BIS(2,6-DICHLORO-4-HYDROXYPHENYL)ETHYLENEDIAMINE]-DICHLOROPLATINUM(II), A NEW DRUG NOT ONLY PARENTERALLY BUT ALSO ORALLY-ACTIVE IN THE THERAPY OF BREAST AND PROSTATE-CANCER
SPRUSS, T
SCHERTL, S
SCHNEIDER, MR
GUST, R
BAUER, K
SCHONENBERGER, H
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1993, 119 (12) : 707 - 716
[6] DIAMINE LIGAND RELEASE FROM THE CISPLATIN ANALOG [MESO-1,2-BIS(2,6-DICHLORO-4-HYDROXYPHENYL)ETHYLENEDIAMINE]DICHLOROPLATINUM(II) IN CELL-CULTURE MEDIUM
BEDNARSKI, PJ
TRUMBACH, B
KRATOCHWIL, NA
SCHONENBERGER, H
JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (23) : 4479 - 4485
[7] Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) act as an immune response modifier?: IV.: Inhibition of the proliferation-increasing effect of progressively growing MXT-M-3,2 breast cancer on phagocytes by the title compound
Schlemmer, R
Spruss, T
Bernhardt, G
Schönenberger, H
ARCHIV DER PHARMAZIE, 2001, 334 (10) : 309 - 317
[8] Structure activity studies on leaving group derivatives of [meso-1,2-bis-(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]-platinum(II)
Gust, R
Keilitz, R
Krauser, R
Schmidt, K
Schnurr, B
ARCHIV DER PHARMAZIE, 1999, 332 (08) : 261 - 270
[9] Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]-dichloro-platinum(II) act as an immune response modifier?: Part III:: Progressively growing MXT-M-3,2 breast cancer stimulates the proliferation of phagocytes in B6D2F1 mice
Schlemmer, R
Spruss, T
Bernhardt, G
Schönenberger, H
ARCHIV DER PHARMAZIE, 2000, 333 (12) : 404 - 414
[10] REDUCTION OF THE ESTROGENIC SIDE-EFFECTS OF THE MAMMARY TUMOR-INHIBITING DRUG [1,2-BIS(2,6-DICHLORO-4-HYDROXYPHENYL)-ETHYLENEDIAMINE]DICHLOROPLATINUM(II) BY VARIATION OF RING SUBSTITUENTS
GUST, R
KARL, J
FADERL, M
SCHONENBERGER, H
ARCHIV DER PHARMAZIE, 1995, 328 (05) : 457 - 463

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