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- [6] Phase IV Clinical Study to Evaluate the Efficacy and Safety of AVONEX® (Interferon-β-1a) in Japanese Subjects with Relapsing Form of Multiple Sclerosis (MS) and the Effect of Dose Titration on Severity and Incidence of Flu-like Symptoms (FLS) MULTIPLE SCLEROSIS JOURNAL, 2014, 20 (07) : 925 - 925