Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

被引：6

作者：

Masereel, B ^{[1
]}

Ouedraogo, R ^{[1
]}

Dogne, JM ^{[1
]}

Antoine, MH ^{[1
]}

deTullio, P ^{[1
]}

Pirotte, B ^{[1
]}

Pochet, L ^{[1
]}

Delarge, J ^{[1
]}

Lebrun, P ^{[1
]}

机构：

[1] UNIV BRUSSELS,DEPT PHARMACOL,B-1070 BRUSSELS,BELGIUM

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1997年 / 32卷 / 05期

关键词：

sulfonylcyanoguanidine; sulfonamidonitroethylene; insulin secretion; diabetes;

D O I：

10.1016/S0223-5234(97)81682-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Sulfonylcyanoguanidines and sulfonamidonitroethylenes are bioisosteres of hypoglycemic sulfonylureas and were prepared and evaluated for their insulin release potency from rat pancreatic islets. At 25 mu M, both bioisosteres of glibenclamide, sulfonylcyanoguanidine 22 and sulfonamidonitroethylene 23, were as potent as their parent on insulin secretion.

引用

页码：453 / 456

页数：4

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