Discovery of novel class of alpha selective PI3K inhibitors

被引:0
|
作者
Garland, Keira [1 ]
Hanan, Emily [1 ]
Staben, Steven [1 ]
Braun, Marie-Gabrielle [1 ]
Edgar, Kyle [1 ]
Endres, Nick [1 ]
Friedman, Lori [1 ]
Nguyen, Amanda [1 ]
Pang, Jodie [1 ]
Purkey, Hans [1 ]
Salphati, Laurent [1 ]
Schmidt, Stephen [1 ]
Song, Kyung [1 ]
Ultsch, Mark [1 ]
Jaochico, Allan [1 ]
Chan, Connie [1 ]
Eigenbrot, Charles [1 ]
MacLeod, Calum [2 ]
Jackson, Philip [2 ]
Narukulla, Raman [2 ]
Knight, Jamie [2 ]
Yeap, Kuen [2 ]
Messick, Kristen [1 ]
Valle, Nicole [1 ]
Heald, Robert [2 ]
Nannini, Michelle [1 ]
Hamilton, Pat [1 ]
Clausen, Saundra [1 ]
Young, Amy [1 ]
Sampath, Deepak [1 ]
Hong, Rebecca [1 ]
Lee, Man-Ling [1 ]
Blench, Toby [2 ]
Elliott, Richard [2 ]
Lu, Aijun [3 ]
Gu, Xiao-Hu [3 ]
Xin, Jianfeng [3 ]
机构
[1] Genentech Inc, San Francisco, CA USA
[2] Charles River Labs, Harlow, Essex, England
[3] Pharmaron, Beijing, Peoples R China
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
103
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors
    Barlaam, Bernard
    Cosulich, Sabina
    Fitzek, Martina
    Germain, Herve
    Green, Stephen
    Hanson, Lyndsey L.
    Harris, Craig S.
    Hancox, Urs
    Hudson, Kevin
    Lambert-van der Brempt, Christine
    Lamorlette, Maryannick
    Magnien, Francoise
    Ouvry, Gilles
    Page, Ken
    Ruston, Linette
    Ward, Lara
    Delouvrie, Benedicte
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (13) : 3030 - 3035
  • [2] Discovery of novel quinazolinone derivatives as high potent and selective PI3Kδ and PI3Kδ/γ inhibitors
    Ma, Chen-Chen
    Zhang, Cheng-Mei
    Tang, Long-Qian
    Liu, Zhao-Peng
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 151 : 9 - 17
  • [3] Discovery of Potent and Selective PI3Kγ Inhibitors
    Drew, Samuel L.
    Thomas-Tran, Rhiannon
    Beatty, Joel W.
    Fournier, Jeremy
    Lawson, Kenneth, V
    Miles, Dillon H.
    Mata, Guillaume
    Sharif, Ehesan U.
    Yan, Xuelei
    Mailyan, Artur K.
    Ginn, Elaine
    Chen, Jie
    Wong, Kent
    Soni, Divyank
    Dhanota, Puja
    Chen, Pei-Yu
    Shaqfeh, Stefan G.
    Meleza, Cesar
    Pham, Amber T.
    Chen, Ada
    Zhao, Xiaoning
    Banuelos, Jesus
    Jin, Lixia
    Schindler, Ulrike
    Walters, Matthew J.
    Young, Stephen W.
    Walker, Nigel P.
    Leleti, Manmohan Reddy
    Powers, Jay P.
    Jeffrey, Jenna L.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (19) : 11235 - 11257
  • [4] Discovery of a Novel Series of Thienopyrimidine as Highly Potent and Selective PI3K Inhibitors
    Han, Fangbin
    Lin, Songwen
    Liu, Peng
    Liu, Xiujie
    Tao, Jing
    Deng, Xiaobing
    Yi, Chongqin
    Xu, Heng
    [J]. ACS MEDICINAL CHEMISTRY LETTERS, 2015, 6 (04): : 434 - 438
  • [5] Discovery, Optimization, and Evaluation of Potent and Highly Selective PI3Kγ-PI3Kδ Dual Inhibitors
    Jia, Hong
    Dai, Guangxiu
    Su, Weiguo
    Xiao, Kun
    Weng, Jianyang
    Zhang, Zhulin
    Wang, Qing
    Yuan, Tianhai
    Shi, Fuying
    Zhang, Zheng
    Chen, Wei
    Sai, Yang
    Wang, Jian
    Li, Xiong
    Cai, Yu
    Yu, Jun
    Ren, Ping
    Venable, Jennifer
    Rao, Tadimeti
    Edwards, James P.
    Bembenek, Scott D.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (10) : 4936 - 4948
  • [6] Discovery of fluoroquinolone derivatives as potent, selective inhibitors of PI3Kγ
    Sha, Shao
    Han, Hong-Wei
    Gao, Fei
    Liu, Tian-Bao
    Li, Zhen
    Xu, Chi
    Zhong, Wei-Qing
    Zhu, Hai-Liang
    [J]. MEDCHEMCOMM, 2015, 6 (11) : 2029 - 2035
  • [7] Discovery of Novel Azaindoles as Potent and Selective PI3Kδ Inhibitors for Treatment of Multiple Sclerosis
    Yu, Mengyao
    Wang, Xian
    Tang, Yongmei
    Wang, Longling
    Hu, Xueping
    Weng, Qinjie
    Wang, Jiajia
    Cui, Sunliang
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (11) : 9628 - 9644
  • [8] Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3Kγ Inhibitors
    Bandarage, Upul K.
    Aronov, Alex M.
    Cao, Jingrong
    Come, Jon H.
    Cottrell, Kevin M.
    Davies, Robert J.
    Giroux, Simon
    Jacobs, Marc
    Mahajan, Sudipta
    Messersmith, David
    Moody, Cameron S.
    Swett, Rebecca
    Xu, Jinwang
    [J]. ACS MEDICINAL CHEMISTRY LETTERS, 2021, 12 (01): : 129 - 135
  • [9] Development of novel, selective and irreversible PI3Kδ inhibitors
    Dalton, Samuel
    Campos, Sebastien
    Bush, Jacob
    Thomas, Daniel
    Convery, Maire
    Murphy, John
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [10] Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors
    Hoegenauer, Klemens
    Soldermann, Nicolas
    Zecri, Frederic
    Strang, Ross S.
    Grayeleau, Nadege
    Wolf, Romain M.
    Cooke, Nigel G.
    Smith, Alexander B.
    Hollingworth, Gregory J.
    Blanz, Joachim
    Gutmann, Sascha
    Rummel, Gabriele
    Littlewood-Evans, Amanda
    Burkhart, Christoph
    [J]. ACS MEDICINAL CHEMISTRY LETTERS, 2017, 8 (09): : 975 - 980