The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description

被引：29

作者：

Paterson, Louise M. ^{[1
]}

Flechais, Remy S. A. ^{[1
]}

Murphy, Anna ^{[2
]}

Reed, Laurence J. ^{[1
]}

Abbott, Sanja ^{[3
]}

Boyapati, Venkataramana ^{[2
]}

Elliott, Rebecca ^{[2
]}

Erritzoe, David ^{[1
]}

Ersche, Karen D. ^{[3
,4
]}

Faluyi, Yetunde ^{[5
]}

Faravelli, Luca ^{[1
]}

Fernandez-Egea, Emilio ^{[3
,4
,5
]}

Kalk, Nicola J. ^{[1
]}

Kuchibatla, Shankar S. ^{[2
]}

McGonigle, John ^{[1
]}

Metastasio, Antonio ^{[2
,6
]}

Mick, Inge ^{[1
]}

Nestor, Liam ^{[1
,7
]}

Orban, Csaba ^{[1
]}

Passetti, Filippo ^{[1
,3
,4
]}

Rabiner, Eugenii A. ^{[8
]}

Smith, Dana G. ^{[3
,9
]}

Suckling, John ^{[3
,4
,5
]}

Tait, Roger ^{[3
]}

Taylor, Eleanor M. ^{[2
]}

Waldman, Adam D. ^{[10
]}

Robbins, Trevor W. ^{[3
,9
]}

Deakin, J. F. William ^{[2
]}

Nutt, David J. ^{[1
]}

Lingford-Hughes, Anne R. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Ctr Neuropsychopharmacol, London W12 0NN, England

[2] Univ Manchester, Neurosci & Psychiat Unit, Manchester, Lancs, England

[3] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge, England

[4] Univ Cambridge, Dept Psychiat, Cambridge, England

[5] Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England

[6] 5 Boroughs Partnership NHS Fdn Trust, Warrington, Cheshire, England

[7] GlaxoSmithKline, Clin Res Unit, Cambridge, England

[8] Imanova Ltd, London, England

[9] Univ Cambridge, Dept Psychol, Cambridge, England

[10] Univ London Imperial Coll Sci Technol & Med, Ctr Neuroinflammat & Neurodegenerat, London W12 0NN, England

来源：

JOURNAL OF PSYCHOPHARMACOLOGY | 2015年 / 29卷 / 09期

关键词：

Addiction; functional magnetic resonance imaging; mu-opioid receptor; neurokinin; 1; receptor; dopamine D3 receptor; DOPAMINE D-3 RECEPTOR; POSITRON-EMISSION-TOMOGRAPHY; ANTERIOR CINGULATE CORTEX; SUBSTANCE-USE DISORDERS; INFERIOR FRONTAL GYRUS; GO/NO-GO TASKS; RESPONSE-INHIBITION; NEUROIMAGING EVIDENCE; ALCOHOL DEPENDENCE; PREFRONTAL CORTEX;

D O I：

10.1177/0269881115596155

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Drug and alcohol dependence are global problems with substantial societal costs. There are few treatments for relapse prevention and therefore a pressing need for further study of brain mechanisms underpinning relapse circuitry. The Imperial College Cambridge Manchester (ICCAM) platform study is an experimental medicine approach to this problem: using functional magnetic resonance imaging (fMRI) techniques and selective pharmacological tools, it aims to explore the neuropharmacology of putative relapse pathways in cocaine, alcohol, opiate dependent, and healthy individuals to inform future drug development. Addiction studies typically involve small samples because of recruitment difficulties and attrition. We established the platform in three centres to assess the feasibility of a multisite approach to address these issues. Pharmacological modulation of reward, impulsivity and emotional reactivity were investigated in a monetary incentive delay task, an inhibitory control task, and an evocative images task, using selective antagonists for mu-opioid, dopamine D3 receptor (DRD3) and neurokinin 1 (NK1) receptors (naltrexone, GSK598809, vofopitant/aprepitant), in a placebo-controlled, randomised, crossover design. In two years, 609 scans were performed, with 155 individuals scanned at baseline. Attrition was low and the majority of individuals were sufficiently motivated to complete all five sessions (n=87). We describe herein the study design, main aims, recruitment numbers, sample characteristics, and explain the test hypotheses and anticipated study outputs.

引用

页码：943 / 960

页数：18

共 1 条

[1] The ICCAM platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part B: fMRI description
McGonigle, John
Murphy, Anna
Paterson, Louise M.
Reed, Laurence J.
Nestor, Liam
Nash, Jonathan
Elliott, Rebecca
Ersche, Karen D.
Flechais, Remy S. A.
Newbould, Rexford
Orban, Csaba
Smith, Dana G.
Taylor, Eleanor M.
Waldman, Adam D.
Robbins, Trevor W.
Deakin, J. F. William
Nutt, David J.
Lingford-Hughes, Anne R.
Suckling, John
[J]. JOURNAL OF PSYCHOPHARMACOLOGY, 2017, 31 (01) : 3 - 16

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