Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells' activity

被引：10
|
作者：
Tanabe, T
Ogamino, T
Shimizu, Y
Imoto, M
Nishiyama, S
机构：
[1] Keio Univ, Fac Sci & Technol, Dept Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan
[2] Keio Univ, Fac Sci & Technol, Dept Biosci & Informat, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 08期
关键词：
Verbena littoralis; verbenachalcone; littorachalcone; anodic oxidation; NGF-mediated neurite outgrowth;
D O I：
10.1016/j.bmc.2005.11.055
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Synthesis of the verbenachalcone derivatives 3-5 involving littorachalcone 2 from diaryl ether 7 enabled an SAR Study of enhancement activity against the NGF-mediated neurite outgrowth from PC12D cells. Littorachalcone 2 and o-deoxyverbenachalcone 5 showed similar activity to that of verbenachalcone 1. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2753 / 2762
页数：10
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