Poor Outcome of RUNX1-Mutated (RUNX1-mut) Patients (Pts) with Primary, Cytogenetically Normal Acute Myeloid Leukemia (CN-AML) and Associated Gene- and MicroRNA (miR) Expression Signatures

被引：0

作者：

Mendler, Jason H. ^{[1
]}

Maharry, Kati ^{[1
]}

Radmacher, Michael D. ^{[1
]}

Mrozek, Krzysztof ^{[1
]}

Kohlschmidt, Jessica ^{[1
]}

Nicolet, Deedra ^{[1
]}

Becker, Heiko ^{[1
]}

Metzeler, Klaus H. ^{[1
]}

Schwind, Sebastian ^{[1
]}

Whitman, Susan P. ^{[1
]}

Blum, William ^{[1
]}

Powell, Bayard L. ^{[2
]}

Kolitz, Jonathan E. ^{[3
]}

Carter, Thomas H. ^{[4
]}

Wetzler, Meir ^{[5
]}

Moore, Joseph O. ^{[6
]}

Carroll, Andrew J. ^{[7
]}

Baer, Maria R. ^{[8
]}

Larson, Richard A. ^{[9
]}

Caligiuri, Michael A. ^{[1
]}

Marcucci, Guido ^{[10
]}

Bloomfield, Clara D. ^{[1
]}

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

[2] Wake Forest Univ, Ctr Comprehens Canc, Winston Salem, NC 27109 USA

[3] N Shore Long Isl Jewish Hlth Syst, Dept Med, Lake Success, NY USA

[4] Univ Iowa, Iowa City, IA USA

[5] Roswell Pk Canc Inst, Buffalo, NY 14263 USA

[6] Duke Univ, Med Ctr, Durham, NC USA

[7] Univ Alabama, Dept Genet, Birmingham, AL USA

[8] Univ Maryland, Greenebaum Canc Ctr, Baltimore, MD 21201 USA

[9] Univ Chicago, Chicago, IL 60637 USA

[10] Ohio State Univ, Div Hematol, Columbus, OH 43210 USA

来源：

BLOOD | 2011年 / 118卷 / 21期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：1476 / 1477

页数：2

共 43 条

[1] RUNX1 Mutations Are Associated With Poor Outcome in Younger and Older Patients With Cytogenetically Normal Acute Myeloid Leukemia and With Distinct Gene and MicroRNA Expression Signatures
Mendler, Jason H.
Maharry, Kati
Radmacher, Michael D.
Mrozek, Krzysztof
Becker, Heiko
Metzeler, Klaus H.
Schwind, Sebastian
Whitman, Susan P.
Khalife, Jihane
Kohlschmidt, Jessica
Nicolet, Deedra
Powell, Bayard L.
Carter, Thomas H.
Wetzler, Meir
Moore, Joseph O.
Kolitz, Jonathan E.
Baer, Maria R.
Carroll, Andrew J.
Larson, Richard A.
Caligiuri, Michael A.
Marcucci, Guido
Bloomfield, Clara D.
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (25) : 3109 - 3118
[2] Residual Disease in a Novel Xenograft Model of RUNX1-Mutated, Cytogenetically Normal Acute Myeloid Leukemia
Sivagnanalingam, Umayal
Balys, Marlene
Eberhardt, Allison
Wang, Nancy
Myers, Jason R.
Ashton, John M.
Becker, Michael W.
Calvi, Laura M.
Mendler, Jason H.
PLOS ONE, 2015, 10 (07):
[3] Higher MN1 expression is an unfavorable prognosticator in older patients (Pts) with cytogenetically normal acute myeloid leukemia (CN-AML): A CALGB study
Schwind, Sebastian
Marcucci, Guido
Holland, Kelsi B.
Mrozek, Krzysztof
Michael, Radmacher D.
Maharry, Kati
Becker, Heiko
Whitman, Susan P.
Wu, Yue-Zhong
Carter, Thomas H.
Powell, Bayard L.
Caligiuri, Michael A.
Baer, Maria R.
Larson, Richard A.
Bloomfield, Clara D.
CANCER RESEARCH, 2010, 70
[4] High expression of RUNX1 is associated with poorer outcomes in cytogenetically normal acute myeloid leukemia
Fu, Lin
Fu, Huaping
Tian, Lei
Xu, Keman
Hu, Kai
Wang, Jing
Wang, Jijun
Jing, Hongmei
Shi, Jinlong
Ke, Xiaoyan
ONCOTARGET, 2016, 7 (13) : 15828 - 15839
[5] Low Meningioma 1 (MN1) gene expression to predict outcome in cytogenetically normal acute myeloid leukemia (CN-AML): A Cancer and Leukemia Group B (CALGB) study
Langer, C.
Maharry, K.
Mrozek, K.
Paschka, P.
Whitman, S. P.
Kolitz, J. E.
Larson, R. A.
Marcucci, G.
Bloomfield, C. D.
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
[6] MicroRNA (miR) expression signatures in molecular subsets of cytogenetically normal (CN) acute myeloid leukemia (AML): A Cancer and Leukemia Group B (CALGB) study
Radmacher, M. D.
Marcucci, G.
Paschka, P.
Vukosavljevic, T.
Whitman, S. P.
Ruppert, A. S.
Mrozek, K.
Kolitz, J. E.
Larson, R. A.
Bloomfield, C. D.
JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (18)
[7] Mutational Profile and Clinical Outcome in RUNX1-Mutated Acute Myeloid Leukemia, Not Otherwise Specified (AML, NOS) and Acute Myeloid Leukemia with Myelodysplastic-Related Changes (AML-MRC)
Nguyen, Lynh
Zhang, Ling
Zhang, Xiaohui
Song, Jinming
Braswell, Diana S.
MODERN PATHOLOGY, 2018, 31 : 541 - 541
[8] Mutational Profile and Clinical Outcome in RUNX1-Mutated Acute Myeloid Leukemia, Not Otherwise Specified (AML, NOS) and Acute Myeloid Leukemia with Myelodysplastic-Related Changes (AML-MRC)
Lynh Nguyen
Zhang, Ling
Zhang, Xiaohui
Song, Jinming
Braswell, Diana S.
LABORATORY INVESTIGATION, 2018, 98 : 541 - 541
[9] Distinct Gene Expression Profiles and Mutations Associate with Outcome in Younger Adults with De Novo Cytogenetically Normal Acute Myeloid Leukemia (CN-AML) (Alliance)
Walker, Christopher J.
Eisfeld, Ann-Kathrin
Ozer, Hatice G.
Kohlschmidt, Jessica
Nicolet, Deedra
Mrozek, Krzysztof
Papaioannou, Dimitrios
Genutis, Luke K.
Powell, Bayard L.
Uy, Geoffrey L.
Kolitz, Jonathan E.
Carroll, Andrew J.
Stone, Richard
Garzon, Ramiro
Byrd, John C.
de la Chapelle, Albert
Bloomfield, Clara D.
BLOOD, 2019, 134
[10] RUNX1 mutations in cytogenetically normal acute myeloid leukemia are associated with a poor prognosis and up-regulation of lymphoid genes
Greif, Philipp A.
Konstandin, Nikola P.
Metzeler, Klaus H.
Herold, Tobias
Pasalic, Zlatana
Ksienzyk, Bianka
Dufour, Annika
Schneider, Friederike
Schneider, Stephanie
Kakadia, Purvi M.
Braess, Jan
Sauerland, Maria Cristina
Berdel, Wolfgang E.
Buechner, Thomas
Woermann, Bernhard J.
Hiddemann, Wolfgang
Spiekermann, Karsten
Bohlander, Stefan K.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2012, 97 (12): : 1909 - 1915

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