Chemometrical identification of mutations in HIV-1 reverse transcriptase conferring resistance or enhanced sensitivity to arylsulfonylbenzonitriles

被引：21

作者：

Rodríguez-Barrios, F ^{[1
]}

Gago, F ^{[1
]}

机构：

[1] Univ Alcala de Henares, Fac Farmacol, E-28871 Alcala De Henares, Madrid, Spain

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 09期

关键词：

D O I：

10.1021/ja038893t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A comparative binding energy (COMBINE) analysis on a series of nonnucleosidic reverse transcriptase inhibitors yields a QSAR model with high predictive ability and correctly identifies the effect of mutations on relevant protein residues. Copyright © 2004 American Chemical Society.

引用

页码：2718 / 2719

页数：2

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