Cyclophilin Inhibitors for Hepatitis C Therapy

被引：20

作者：

Membreno, Fernando E. ^{[1
]}

Espinales, Jennifer C. ^{[2
]}

Lawitz, Eric J. ^{[1
]}

机构：

[1] Alamo Med Res, San Antonio, TX 78215 USA

[2] Univ Texas Brownsville, Dept Biol Sci, Brownsville, TX 78520 USA

来源：

CLINICS IN LIVER DISEASE | 2013年 / 17卷 / 01期

关键词：

Cyclophilin; Cyclophilin inhibitors; Debio; 025; NIM; 811; SCY-635; Alisporivir; Non-interferon; Interferon-free; NONIMMUNOSUPPRESSIVE CYCLOSPORINE ANALOG; VIRUS-INFECTION; ANTIVIRAL ACTIVITY; DEBIO; 025; A ANALOG; IN-VITRO; HCV; NIM811; REPLICATION; RESISTANCE;

D O I：

10.1016/j.cld.2012.09.008

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This article highlights a unique time in the history of Hepatitis C therapy. In the last few years new families of direct-acting antivirals have emerged, that block different viral proteins to interrupt viral replication, such as protease, NS5A inhibitors, and NS5B inhibitors. There are few host-targeted agents in development; currently cyclophilin inhibitors are the only host-targeted agents in advanced development. One of these new agents has now progressed to phase 3 clinical trials; in this review article their potential role as a future therapy to cure Hepatitis C is discussed.

引用

页码：129 / +

页数：13

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