Enhanced activation of the MKK4/JNK/p38 kinase pathway and decreased mitochondrial membrane potential by bisindolylmaleimide VIII facilitate DR5-mediated apoptosis

被引:0
|
作者
Ohtsuka, T
Zhou, T
机构
[1] Sankyo Co Ltd, Shinagawa Ku, Tokyo 1408710, Japan
[2] Univ Alabama, Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA
来源
FASEB JOURNAL | 2002年 / 16卷 / 04期
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:A142 / A142
页数:1
相关论文
共 16 条
  • [1] Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways
    Ohtsuka, T
    Zhou, T
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (32) : 29294 - 29303
  • [2] Role of JNK/p38 signaling pathway in DR5-mediated apoptosis
    Ohtsuka, T
    Zhou, T
    FASEB JOURNAL, 2001, 15 (04): : A709 - A709
  • [3] Knockdown of Sec8 enhances the binding affinity of c-Jun N-terminal kinase (JNK)-interacting protein 4 for mitogen-activated protein kinase kinase 4 (MKK4) and suppresses the phosphorylation of MKK4, p38, and JNK, thereby inhibiting apoptosis
    Tanaka, Toshiaki
    Iino, Mitsuyoshi
    Goto, Kaoru
    FEBS JOURNAL, 2014, 281 (23) : 5237 - 5250
  • [4] JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation, mitochondrial translocation and apoptosis: a novel mechanism
    Kim, BJ
    Song, BJ
    FASEB JOURNAL, 2006, 20 (04): : A120 - A120
  • [5] Aplidin™ induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C δ
    García-Fernández, LF
    Losada, A
    Alcaide, V
    Alvarez, AM
    Cuadrado, A
    González, L
    Nakayama, K
    Nakayama, KI
    Fernández-Sousa, JM
    Muñoz, A
    Sánchez-Puelles, JM
    ONCOGENE, 2002, 21 (49) : 7533 - 7544
  • [6] Aplidin™ induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C δ
    Luis F García-Fernández
    Alejandro Losada
    Victoria Alcaide
    Alberto M Álvarez
    Ana Cuadrado
    Laura González
    Keiko Nakayama
    Keiichi I Nakayama
    José María Fernández-Sousa
    Alberto Muñoz
    José María Sánchez-Puelles
    Oncogene, 2002, 21 : 7533 - 7544
  • [7] Cell-free methemoglobin drives platelets to apoptosis via mitochondrial ROS-mediated activation of JNK and p38 MAP kinase
    NaveenKumar, Somanathapura K.
    Hemshekhar, Mahadevappa
    Sundaram, Mahalingam S.
    Kemparaju, Kempaiah
    Girish, Kesturu S.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 491 (01) : 183 - 191
  • [8] Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta
    Garcia-Fernandez, LF
    Cuadrado, A
    Losada, A
    Gonzalez, L
    Alcaide, V
    Martinez, T
    Alvarez, A
    Fernandez-Sousa, JM
    Muñoz, A
    Sanchez-Puelles, JM
    EUROPEAN JOURNAL OF CANCER, 2002, 38 : S165 - S165
  • [9] GLUD1 inhibits hepatocellular carcinoma progression via ROS-mediated p38/JNK MAPK pathway activation and mitochondrial apoptosis
    Zhao, Qianwei
    Yu, Mengdan
    Li, Jinxia
    Guo, Yaoyu
    Wang, Zexuan
    Hu, Kefei
    Xu, Fang
    Liu, Yixian
    Li, Lili
    Wan, Didi
    Zhao, Ying
    Shang, Jian
    Zhang, Jintao
    DISCOVER ONCOLOGY, 2024, 15 (01)
  • [10] GLUD1 inhibits hepatocellular carcinoma progression via ROS-mediated p38/JNK MAPK pathway activation and mitochondrial apoptosis
    Qianwei Zhao
    Mengdan Yu
    Jinxia Li
    Yaoyu Guo
    Zexuan Wang
    Kefei Hu
    Fang Xu
    Yixian Liu
    Lili Li
    Didi Wan
    Ying Zhao
    Jian Shang
    Jintao Zhang
    Discover Oncology, 15