Hypervalent iodine(V) mediated mild and convenient synthesis of substituted 2-amino-1,3,4-oxadiazoles

被引：34
|
作者：
Prabhu, Girish [1 ]
Sureshbabu, V. V. [1 ]
机构：
[1] Bangalore Univ, Peptide Res Lab, Dept Studies Chem, Bangalore 560001, Karnataka, India
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 32期
关键词：
Hypervalent iodine reagent; IBX; Oxadiazole; Desulfurization; POLYMER-SUPPORTED REAGENTS; 2-IODOXYBENZOIC ACID IBX; SOLID-PHASE SYNTHESIS; POLYVALENT IODINE; 1,3-DISUBSTITUTED THIOUREAS; EFFICIENT SYNTHESIS; ORGANIC-SYNTHESIS; 1,3,4-OXADIAZOLES; DERIVATIVES; AGENTS;
D O I：
10.1016/j.tetlet.2012.05.154
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple protocol for the synthesis of 2-amino-1,3,4-oxadiazoles starting from the corresponding acylhydrazides by cyclodesulfurization of intermediate acylthiosemicarbazides mediated by o-iodoxybenzoic acid in good yields has been described. The protocol is mild with wide substrate scope, and thus a range of 2-amino-1,3,4-oxadiazoles have been prepared. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4232 / 4234
页数：3
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