Regioselective synthesis of novel 4-aryl-2-ethylthio-7-methyl pyrazolo[1,5-a]-[1,3,5]-triazines

被引：20
|
作者：
Insuasty, Henry
Estrada, Martin
Cortes, Edward
Quiroga, Jairo
Insusasty, Braulio
Abonia, Rodrigo
Nogueras, Manuel
Cobo, Justo
机构：
[1] Univ Narino, Dept Chem, Grp Invest Sintesis Compuestos Heterociclicos, Pasto, Colombia
[2] Univ Valle, Dept Chem, Grp Invest Compuestos Heterociclicos, Cali, Colombia
[3] Univ Jaen, Dept Inorgan & Organ Chem, Jaen 23071, Spain
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 31期
关键词：
5-amino-3-methylpyrazole; S; S-diethyl aroyliminodithio-carbonates; aroyl isothiocyanates; pyrazolo[1,5-a]-[1,3,5]-triazines; thioureas; isothioureas;
D O I：
10.1016/j.tetlet.2006.05.168
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pyrazolo[1,5-a]-[1,3,5]-triazines 6a-d were obtained by an efficient one-step reaction front S,S-diethyl aroyliminodithiocarbonates 4a-d and 5-amino-3-methylpyrazole 5 or by an alternative two-step reaction from 5 and aroyl isothiocyanates 8a-d to give initially the thiourea derivatives 9a-d, which after S-ethylation and cyclization afforded compounds 6a-d. The intermediate 7a isolated from reaction between 4a and 5 permitted us to establish the orientation. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5441 / 5443
页数：3
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