Polyamidoamine dendrimer conjugated chitosan nanoparticles for the delivery of methotrexate

被引：34
|
作者：
Leng, Zhen-Hua [1 ,2 ]
Zhuang, Qian-Fen [2 ]
Li, Yan-Chao [2 ]
He, Zeng [3 ,4 ]
Chen, Zhao [2 ]
Huang, Sai-Peng [2 ]
Jia, Hong-Ying [2 ]
Zhou, Jian-Wei [1 ]
Liu, Yang [2 ]
Du, Li-Bo [2 ]
机构：
[1] Guizhou Normal Univ, Sch Chem & Mat Sci, Guiyang, Guizhou, Peoples R China
[2] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100080, Peoples R China
[3] Chinese Acad Med Sci, Inst Blood Transfus, Chengdu, Sichuan, Peoples R China
[4] Peking Union Med Coll, Chengdu, Sichuan, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2013年 / 98卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Chitosan; Nanoparticles; PAMAM; Drug delivery; Methotrexate; IN-VITRO; PAMAM; DOXORUBICIN; CHEMISTRY; THERAPY; DRUG; PPI;
D O I：
10.1016/j.carbpol.2013.07.021
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Encapsulating anticancer drugs to synthetic polymer is a promising approach to improve the efficiency and reduce the side effects of anticancer drugs. In this study, novel chitosan derivatives with polyamidoamine moieties (CS-PAMAM) were synthesized and characterized by morphology, particle size, and zeta potential. Then the anticancer drug-methotrexate-encapsulated CS-PAMAM was prepared by hydrophobic-hydrophilic interactions. The drug release assay showed that the amount of the methotrexate release from CS-PAMAM was pH depended. Meanwhile, the cell viability assay illustrated that CS-PAMAM was suitable for the drug delivery because of its low cytotoxicity on cells. Moreover, our results showed that the CS-PAMAM could significantly improve the cytotoxicity of free methotrexate on A549 cells. These results demonstrate that CS-PAMAM may provide a suitable platform for the water-insoluble drug delivery. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1173 / 1178
页数：6
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