Increase in single L-type calcium channels in hippocampal neurons during aging

被引：399
|
作者：
Thibault, O [1 ]
Landfield, PW [1 ]
机构：
[1] UNIV KENTUCKY, COLL MED, DEPT PHARMACOL, LEXINGTON, KY 40536 USA
来源：
SCIENCE | 1996年 / 272卷 / 5264期
关键词：
D O I：
10.1126/science.272.5264.1017
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Voltage-activated calcium (Ca2+) influx is increased in mammalian CA1 hippocampal neurons during aging. However, the molecular basis for this elevation is not known. The partially dissociated hippocampal (''zipper'') slice preparation was used to analyze single Ca2+ channel activity in CA1 neurons of adult and aged rats. Total L-type Ca2+ channel activity in patches was found to increase with aging, primarily because of an increase in the density of functional channels. Learning in aged animals was inversely correlated with channel density, This increase in functional Ca2+ channels with aging could underlie the vulnerability of neurons to age-associated neurodegenerative conditions.
引用
收藏
页码：1017 / 1020
页数：4
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